July 24, 2014
ABCDEFGHIJKLMNOPQRSTUVWXYZ

Weight Management

 Health Home >> Weight Management >> Health news 

Study finds genetic cause for common heart ailment

Provided by: RELAXNEWS
Written by: Relaxnews
Feb. 7, 2013

(Dariush M./shutterstock.com)


A genetic variation doubles the risk of developing calcium deposits in the heart, a common condition that, in severe cases, can narrow or block the aorta, according to a study published Wednesday.

The genetic variation, found in 7% of the population, provides important clues about how to treat the disease, researchers said in the study published in the New England Journal of Medicine.

"This is an important step forward in understanding the biology of the development of aortic stenosis," said senior author Wendy Post, from the Johns Hopkins University School of Medicine.

Ad
She added that the latest findings could lead to the development of targeted medications to slow the progression of the disease, which can cause chest pain and shortness of breath, and can in some cases require surgery.

The gene in question is involved in the production of a type of cholesterol particle called lipoprotein (a), which circulates in the blood.

"Increased levels of lipoprotein (a) have been previously associated with aortic valve disease. However, prior studies could not differentiate whether it was simply a marker or a causal factor," said lead author Catherine Campbell, of Kaiser Permanente.

"Our results provide the first evidence for a causal relationship," she added.

The researchers studied 2.5 million gene variants among more than 6,900 people of white European heritage, and they found that the particular variant was strongly associated with the aortic calcium deposits.

The scientists then confirmed the link in studies with three other groups -- more than 2,000 people of Hispanic origin, about 2,500 African-Americans, and more than 700 Germans.

They also demonstrated that the gene variant was linked to a future risk of developing the heart condition, using data from nearly 40,000 people in Sweden and Denmark.

Other risk factors for developing aortic stenosis include advancing age, high blood pressure, obesity, high cholesterol levels and smoking. Men are at higher risk than women.

js/nss/jk

View more news


Did you find what you were looking for on our website? Please let us know.

The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical condition(s) and treatment(s). This site is not a substitute for medical advice.

© 1996 - 2014 MediResource Inc. - MediResource reaches millions of Canadians each year.