September 22, 2014
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Drug Factsheets

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Trental

(pentoxifylline)

DIN (Drug Identification Number)

02221977 TRENTAL 400MG TABLET (SUSTAINED RELEASE)

How does Trental work? What will it do for me?

Pentoxifylline belongs to the group of medications called vasoactive agents. These medications work by improving blood flow in the arms and legs. Pentoxifylline is used to treat chronic circulation disorders of the arms and legs, such as intermittent claudication (peripheral arterial disease) or ulcers due to poor blood supply. It may allow further distances to be walked before leg pain or cramps occur. It may take up to 2 months to see the full benefits of the medication.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Trental?

The usual recommended adult starting dose of pentoxifylline is 400 mg twice daily after meals. Your doctor may adjust the dose over time as needed to a maximum of 400 mg 3 times daily. The tablets must be swallowed whole - do not crush or chew the tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Trental come in?

Each pink, oblong, film-coated, sustained-release tablet contains pentoxifylline 400 mg. Nonmedicinal ingredients: FD&C Red No. 3, hydroxyethyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol, povidone, talc, and titanium dioxide.

Who should NOT take Trental?

Do not take pentoxifylline if you:

  • are allergic to pentoxifylline, to the class of medications called xanthines (e.g., caffeine, theophylline, and theobromine), or to any of the ingredients of the medication
  • are bleeding or at risk of increased bleeding
  • are having a heart attack
  • have severe coronary artery disease and, in the doctor's judgment, stimulation of the heart could prove harmful
  • have or have recently had a stomach or intestinal ulcer

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