July 25, 2014
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Drug Factsheets

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Apo-Pentoxifylline SR

(pentoxifylline)

DIN (Drug Identification Number)

02230090 APO-PENTOXIFYLLINE SR 400MG TABLET (SUSTAINED-RELEASE)

What side effects are possible with Apo-Pentoxifylline SR?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • bloating
  • diarrhea
  • dizziness or lightheadedness
  • flushing
  • general feeling of discomfort or feeling unwell
  • headache
  • heartburn
  • nausea
  • stomach discomfort
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • irregular heartbeat

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • bleeding (blood in your stool or bleeding around your eyes)
  • chest pain
  • difficulty breathing
  • symptoms of an allergic reaction, e.g.:
    • blisters
    • itching
    • red spots
    • swelling

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Apo-Pentoxifylline SR?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Bleeding: The use of pentoxifylline has been associated with bleeding and prolonged clotting time. The risk of bleeding may be increased by combined treatment with blood-thinning medications such as warfarin. Your doctor will monitor you while you are taking pentoxifylline. If you experience any abnormal bleeding (e.g., bleeding around your eyes or blood in your stool), seek immediate medical attention.

Blood pressure: People with low blood pressure may be more sensitive to side effects with the use of this medication. Your doctor will monitor you while you are taking pentoxifylline.

Liver or kidney disease: People with liver or kidney disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Pentoxifylline is not recommended for people with severely reduced kidney or liver function.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Pentoxifylline passes into breast milk. If you are breast-feeding and are taking pentoxifylline, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children below the age of 18 years.

Seniors: Seniors may be more sensitive to the side effects of this medication. Your doctor will monitor you while you are taking this medication.

What other drugs could interact with Apo-Pentoxifylline SR?

There may be an interaction between pentoxifylline and any of the following:

  • antidiabetes medications (e.g., glyburide, insulin, metformin)
  • blood pressure reducing medications (e.g., metoprolol, ramipril)
  • cimetidine
  • ciprofloxacin
  • erythromycin
  • ketorolac medications that affect blood clotting (e.g., clopidogrel, heparin, warfarin)
  • sympathomimetic medications (e.g., pseudoephedrine)
  • theophylline

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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