September 23, 2014
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Drug Factsheets

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Apo-Divalproex

(divalproex)

DIN (Drug Identification Number)

02239698 APO-DIVALPROEX 125MG TABLET
02239699 APO-DIVALPROEX 250MG TABLET
02239700 APO-DIVALPROEX 500MG TABLET

How does Apo-Divalproex work? What will it do for me?

Divalproex belongs to the family of medications called anticonvulsants. It is used to manage and control of certain types of seizures. It can be used alone or in combination with other seizure control medications. It is also used for people 18 years of age and older with manic depression (bipolar disorder) to treat manic episodes.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Apo-Divalproex?

The recommended adult dose of divalproex to treat seizures is based on weight and the final dose is determined by control of seizures with minimal side effects. The recommended initial dosage is 15 mg per kg of body weight per day. Your doctor may then suggest increasing at one-week intervals by 5 to 10 mg per kg of body weight per day until seizures are controlled or side effects prevent further increases. The maximum recommended dosage is 60 mg per kg of body weight per day.

When taken to treat manic episodes, the starting dose is 250 mg 3 times daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

When the dose of divalproex increases above 250 mg per day, it should be taken in divided doses.

The tablets should be swallowed whole and can be taken with or without food. This medication should not be stopped suddenly due to the possibility of a rebound major seizure.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Apo-Divalproex come in?

125 mg
Each red, oval, biconvex, enteric-coated tablet, engraved "APO" on one side and "125" on the other, contains divalproex sodium equivalent to valproic acid 125 mg. Nonmedicinal ingredients: FD&C Red No. 30 Aluminum Lake, eudragit, FD&C Yellow No. 6, guar gum, hydroxypropyl methylcellulose, hydroxypropyl cellulose, methacrylic acid copolymer dispersion, microcrystalline cellulose, polyethylene glycol, talc, titanium dioxide, and triethyl citrate.

250 mg
Each peach, oval, biconvex, enteric-coated tablet, engraved "APO" on one side and "250" on the other, contains divalproex sodium equivalent to valproic acid 250 mg. Nonmedicinal ingredients: eudragit, FD&C Yellow No. 6, guar gum, hydroxypropyl methylcellulose, hydroxypropyl cellulose, methacrylic acid copolymer dispersion, microcrystalline cellulose, polyethylene glycol, talc, titanium dioxide, and triethyl citrate.

500 mg
Each pink, oval, biconvex, enteric-coated tablet, engraved "APO" on one side and "500" on the other, contains divalproex sodium equivalent to valproic acid 500 mg. Nonmedicinal ingredients: FD&C Red No. 33, eudragit, guar gum, hydroxypropyl methylcellulose, hydroxypropyl cellulose, methacrylic acid copolymer dispersion, microcrystalline cellulose, polyethylene glycol, red ferric oxide (orange shade), talc, titanium dioxide, and triethyl citrate.

Who should NOT take Apo-Divalproex?

Do not take divalproex if you:

  • are allergic to valproic acid, divalproex, or any ingredients of the medication
  • have been diagnosed with a urea cycle disorder
  • have liver disease or a significant reduction in liver function
  • have Alpers syndrome or Alpers-Huttenlocher syndrome, conditions caused by nervous system breakdown
  • have porphyria

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