October 23, 2014
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GlucoNorm

(repaglinide)

DIN (Drug Identification Number)

02239924 GLUCONORM 0.5MG TABLET
02239925 GLUCONORM 1MG TABLET
02239926 GLUCONORM 2MG TABLET

What side effects are possible with GlucoNorm?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • back pain
  • constipation
  • diarrhea
  • headache
  • joint pain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bloody or cloudy urine
  • burning, painful, or difficult urination
  • chills
  • cough
  • fever
  • low blood sugar, including:
    • anxious feeling
    • behavioural change similar to being drunk
    • blurred vision
    • cold sweats
    • confusion
    • cool pale skin
    • difficulty thinking
    • drowsiness
    • excessive hunger
    • fast heartbeat
    • headache
    • nausea
    • nervousness
    • nightmares
    • restless sleep
    • shakiness
    • slurred speech
    • unusual tiredness or weakness
  • problems with teeth
  • runny or stuffy nose
  • shortness of breath
  • signs of liver damage:
    • abdominal pain
    • dark urine
    • fatigue
    • fever
    • loss of appetite
    • yellow skin or eyes
  • sinus congestion with pain
  • sneezing
  • sore throat
  • wheezing

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • convulsions (seizures)
  • fast or irregular heartbeat
  • signs of an allergic reaction, e.g.:
    • difficulty breathing
    • hives
    • swelling of the face or throat
  • signs of bleeding, e.g.:
    • bleeding gums
    • blood in the urine
    • dark tarry stools
    • easy bruising
    • nosebleeds
    • vomiting blood
  • unconsciousness

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for GlucoNorm?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood sugar control: If you are exposed to extra stress such as fever, trauma, infection, or surgery, your blood sugar control may vary. Monitor your blood sugar carefully and call the doctor if any important changes occur in your control.

Hypoglycemia (low blood sugar): Hypoglycemia (low blood sugar) can occur when taking repaglinide. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking this medication, contact your doctor. The blood sugar-lowering effects of repaglinide may be increased when taken together with gemfibrozil. People who are taking gemfibrozil should not take repaglinide.

Liver function: Reduced liver function may cause higher levels of repaglinide in the body and increase the risk for low blood sugar levels (hypoglycemia). Make sure you report all your medical conditions to your doctor(s). People with severe liver disease should not take repaglinide.

Missed or delayed meals: This medication acts by promoting the secretion of insulin and should be taken before meals. If a meal is skipped or delayed, the dosing of repaglinide should be skipped or delayed as well.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, stop taking it immediately and contact your doctor.

Breast-feeding: It is not known whether repaglinide passes into breast milk. Repaglinide is not recommended for breast-feeding women.

Children: This safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with GlucoNorm?

There may be an interaction between repaglinide and any of the following:

  • ACE inhibitors (e.g., ramipril, lisinopril)
  • alcohol
  • anabolic steroids
  • antidiabetic agents
  • barbiturates (e.g., phenobarbital)
  • beta-blockers (e.g., propranolol, metoprolol)
  • birth control pills
  • calcium channel blockers (e.g., nifedipine, verapamil)
  • carbamazepine
  • chloramphenicol
  • clarithromycin
  • corticosteroids (e.g., prednisone)
  • cyclosporine
  • danazol
  • diabetic medications
  • diuretics (e.g., hydrochlorothiazide)
  • gemfibrozil
  • isoniazid
  • itraconazole
  • ketoconazole
  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • miconazole
  • nicotinic acid
  • nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen)
  • octreotide
  • phenobarbital
  • phenothiazines (e.g., chlorpromazine, perphenazine)
  • phenytoin
  • probenecid
  • rifampicin
  • salicylates (e.g., ASA)
  • sulfonamides (e.g., sulfamethoxazole)
  • sympathomimetics (e.g., ephedrine, pseudoephedrine, cough and cold medication)
  • thiazides (diuretics or "water pills")
  • thyroid products (e.g., levothyroxine)
  • trimethoprim
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than the ones listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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