November 1, 2014
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Drug Factsheets

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Humalog

(insulin lispro)

DIN (Drug Identification Number)

02241283 HUMALOG PEN 100 UNITS/ML SOLUTION FOR INJECTION
02229704 HUMALOG 100 UNITS/ML SOLUTION FOR INJECTION
02229705 HUMALOG CARTRIDGE/KWIKPEN 100 UNITS/ML SOL FOR INJ

How does Humalog work? What will it do for me?

Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. Insulin lispro is a rapid-acting insulin. It takes about 10 to 15 minutes after injection to begin working and has its maximum effect between 60 minutes and 150 minutes. It stops working after 3.5 to 5 hours.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

How should I use Humalog?

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin), exactly as instructed by your doctor or diabetes educator. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. Insulin lispro is injected under the skin within 15 minutes before the start of a meal. Longer-acting insulins are often used along with insulin lispro to cover the periods of time between doses of insulin lispro. There are many variations of insulin dosing.

Insulin lispro should be clear and colourless. Do not use the insulin if you notice anything unusual in the appearance of the solution, such as cloudiness, discoloration, or clumping.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. Do not change the way that you are using the medication without consulting your doctor.

It is very important that you use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects.

Keep unopened bottles of insulin in the refrigerator until needed; they may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for 28 days only and then discarded. Do not expose insulin to extremely hot temperatures or to sunlight. Keep insulin out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Humalog come in?

Humalog®

Each 10 mL vial contains 100 units of human insulin analogue (insulin lispro) for every 1 mL. Nonmedicinal ingredients: glycerin, dibasic sodium phosphate, m-Cresol distilled, zinc, water for injection, and hydrochloric acid or sodium hydroxide to adjust for pH.

Humalog® KwikPen™/Cartridge

Every 1 mL contains100 units of human insulin analogue (insulin lispro). Nonmedicinal ingredients: glycerin, dibasic sodium phosphate, m-Cresol distilled, zinc, water for injection, and hydrochloric acid or sodium hydroxide to adjust for pH.

Humalog® Pen

Every 1 mL contains 100 units of human insulin analogue (insulin lispro). Nonmedicinal ingredients: glycerin, dibasic sodium phosphate, m-Cresol distilled, zinc, water for injection, and hydrochloric acid or sodium hydroxide to adjust for pH.

Who should NOT take Humalog?

Insulin lispro should not be used by anyone who:

  • is allergic to insulin or to any of the ingredients of the medication
  • has low blood glucose (hypoglycemia)

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