October 25, 2014
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Drug Factsheets

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Tapazole

(methimazole)

DIN (Drug Identification Number)

00015741 TAPAZOLE 5MG TABLET
02296039 TAPAZOLE 10MG TABLET

What side effects are possible with Tapazole?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • dizziness
  • loss of taste sensation
  • nausea
  • stomach pain
  • vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • backache
  • black, tarry stools
  • blood in urine or stools
  • increase in bleeding or bruising
  • increase or decrease in urination
  • numbness or tingling of fingers, toes, or face
  • pinpoint-sized red spots on skin
  • shortness of breath
  • swelling of feet or lower legs
  • swollen lymph nodes
  • swollen salivary glands
  • symptoms of liver damage (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • cough
  • fever or chills
  • general feeling of discomfort, illness, or weakness
  • headache
  • hoarseness
  • mouth sores
  • pain, swelling, or redness in joints
  • skin rash
  • sore throat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Tapazole?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood tests: Your doctor will likely want you to have laboratory tests done on a regular basis because in rare cases, methimazole can cause the levels of white blood cells to decrease. Low white blood cell levels can increase the risk of infection. If you have a sore throat, skin rash, fever, headache, or a general feeling of being unwell, tell your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Women using methimazole should not breast-feed.

What other drugs could interact with Tapazole?

There may be an interaction between methimazole and any of the following:

  • amiodarone
  • beta-blockers (e.g., atenolol, metoprolol, propranolol)
  • digoxin
  • potassium iodide
  • sodium iodide
  • theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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