July 22, 2014
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Nexium

(esomeprazole)

DIN (Drug Identification Number)

02244521 NEXIUM 20MG TABLET
02244522 NEXIUM 40MG TABLET
02300524 NEXIUM 10MG SACHET

How does Nexium work? What will it do for me?

Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). In adults and children, it is used to treat conditions such as reflux esophagitis (tissue damage caused by stomach contents flowing back up the esophagus) and symptoms of gastroesophageal reflux disease (GERD) in people with reflux esophagitis. It is also used to treat nonerosive reflux disease (NERD; heartburn and regurgitation not related to tissue damage) in children and adults. When combined with other medications, esomeprazole is used to treat duodenal ulcers that are caused by bacteria known as H. pylori.

Esomeprazole can be used to treat or reduce the risk of stomach ulcers due to medications known as NSAIDs (e.g., ibuprofen, naproxen, ketorolac) that irritate the stomach. It is also used to treat conditions associated with the overproduction of stomach acid, including Zollinger-Ellison syndrome.

Esomeprazole works by reducing the amount of acid the stomach produces.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Nexium?

The recommended dose of esomeprazole to treat reflux esophagitis and symptoms of GERD is 40 mg once daily for 4 to 8 weeks. After 8 weeks, treatment may be continued at a dose of 20 mg once daily.

To treat NERD or heartburn, the recommended does is 20 mg taken once daily for 2 to 4 weeks. After this, esomeprazole may be taken at a dose of 20 mg once daily as needed to control symptoms.

To treat stomach ulcers associated with NSAID use, the dose is 20 mg once daily for 4 to 8 weeks. To prevent such ulcers, the dose is 20 mg once daily.

To treat duodenal ulcers caused by H. pylori in adults, the dose of esomeprazole is 20 mg twice daily taken with amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily - all for 7 days.

For children 12 months to 11 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 10 mg to 20 mg (depending on the child's weight) once daily for 8 weeks. For NERD (heartburn and reflux), the recommended dose is 10 mg once daily for up to 8 weeks.

For children 11 to 17 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 20 mg to 40 mg once daily for 4 to 8 weeks. For NERD (heartburn and reflux), the recommended dose is 20 mg once daily for 2 to 4 weeks.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Esomeprazole tablets can be taken with or without food. They should be swallowed whole - do not crush or chew them. Alternatively, the tablet may be stirred into half a glass of noncarbonated water until it disintegrates. Drink the liquid containing the small pellets of medication immediately, or within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.

The sachets of esomeprazole contain granules for oral suspension. Pour all the granules of one sachet into a glass containing one tablespoon (15 mL) of water, stir, and leave for a few minutes to allow the mixture to thicken. Stir again and drink it within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Nexium come in?

Tablets

20 mg
Each light pink, oblong, and biconvex, delayed-release tablet, engraved with "20 mg" on one side and "A" over "EH" on the other side, contains esomeprazole 20 mg equivalent to esomeprazole magnesium trihydrate 22.3 mg. Nonmedicinal ingredients: cellulose microcrystalline, crospovidone, glyceryl monostearate, hydroxypropyl cellulose, hypromellose, iron oxide, magnesium stearate, methacrylic acid ethylacrylate copolymer, polyethylene glycol, polysorbate, sodium stearyl fumarate, sugar spheres, synthetic paraffin, talc, titanium dioxide, and triethyl citrate.

40 mg
Each pink, oblong, and biconvex, delayed-release tablet, engraved with "40 mg" on one side and "A" over "EI" on the other side, contains esomeprazole 40 mg equivalent to esomeprazole magnesium trihydrate 44.5 mg. Nonmedicinal ingredients: cellulose microcrystalline, crospovidone, glyceryl monostearate, hydroxypropylcellulose, hypromellose, iron oxide, magnesium stearate, methacrylic acid ethylacrylate copolymer, polyethylene glycol, polysorbate, sodium stearyl fumarate, sugar spheres, synthetic paraffin, talc, titanium dioxide, and triethyl citrate.

Sachet (granules) for oral suspension

Each sachet of fine pale yellow (may also be brownish) delayed release granules contains 10 mg of esomeprazole. Nonmedicinal ingredients: dextrose, crospovidone, citric acid, glycerol monostearate, hypromellose, hydroxypropyl cellulose, iron oxide, magnesium stearate, methacrylic acid copolymer type C, polysorbate, sugar spheres, talc, triethyl citrate, and xanthan gum.

Who should NOT take Nexium?

Do not take this medication if you are allergic to esomeprazole or any ingredients of the medication.

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