August 20, 2014
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Drug Factsheets

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Norflex

(orphenadrine)

DIN (Drug Identification Number)

01966154 NORFLEX 100MG TABLET
01966162 NORFLEX 30MG/ML INJECTION

What side effects are possible with Norflex?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • confusion
  • constipation
  • dizziness or lightheadedness
  • drowsiness
  • dry mouth
  • excitement, irritability, or nervousness
  • false sense of well-being
  • headache
  • muscle weakness
  • nausea
  • trembling
  • urination difficulties (retention of urine)
  • vision problems
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision
  • dilated pupils
  • fast or pounding heartbeat
  • palpitation
  • unusual tiredness or weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • eye pain
  • fainting
  • hallucinations
  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Norflex?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Contact lenses: Orphenadrine may make the eyes dry, resulting in discomfort or blurred vision if you wear contact lenses.

Dependence: Physical dependence, psychological dependence, and abuse have occurred with the use of orphenadrine. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication.

If you have a history of drug or alcohol use problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Orphenadrine may cause temporary dizziness and lightheadedness. Do not drive, operate machinery, or engage in any potentially hazardous activities until you determine how this medication affects you

Heart disease: Orphenadrine may make the symptoms of certain heart problems worse. If you have coronary insufficiency, irregular heartbeat (arrhythmias), or fast heart rate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: The kidneys help to remove orphenadrine from the body. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: The liver helps to remove orphenadrine from the body. If you have reduced liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if orphenadrine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Orphenadrine is generally not recommended for people who are over the age of 65 due to the increased risk of side effects such as drowsiness and dizziness.

What other drugs could interact with Norflex?

There may be an interaction between orphenadrine and any of the following:

  • alcohol
  • anticholinergic medications (e.g., atropine, scopolomine)
  • antihistamines (e.g., chlorpheniramine, diphenhydramine, hydroxyzine)
  • antipsychotics (e.g., haloperidol, quetiapine, risperidol)
  • baclofen
  • barbiturates (e.g., butalbital, phenobarbital)
  • benzodiazepines (e.g., clonazepam, diazepam, lorazepam)
  • benztropine
  • brimonidine
  • buprenorphine
  • buspirone
  • carbamazepine
  • dimenhydrinate
  • droperidol
  • gabapentin
  • ipratropium
  • lamotrigine
  • levetiracetam
  • MAO inhibitors (e.g., maprotiline, phenelzine, moclobemide)
  • methocarbamol
  • narcotic pain relievers (e.g,. codeine, fentanyl, morphine)
  • phenytoin
  • pimozide
  • potassium chloride
  • propoxyphene
  • St. John's wort
  • tramadol
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, nortriptyline)
  • valerian
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, decongestants, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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