October 2, 2014
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Drug Factsheets

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Puregon

(follitropin beta)

DIN (Drug Identification Number)

02242441 PUREGON 100 UNIT/ 0.5ML
02243948 PUREGON 833 UNIT/ ML
02242439 PUREGON 50 UNIT / 0.5ML

What side effects are possible with Puregon?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • aches and pains
  • breast tenderness
  • chills
  • dry skin
  • fatigue
  • hair loss
  • headache
  • pain, redness, or irritation at the place of injection (temporary)

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • redness, pain, or swelling at injection site (continued)
  • vaginal bleeding

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a severe allergic reaction (shortness of breath, swelling of the face or throat, or hives)
  • symptoms of ovarian hyperstimulation syndrome (OHSS; abdominal or pelvic discomfort or pain, nausea, vomiting, weight gain, difficulty breathing, diarrhea, decreased urination, rapid weight gain)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Puregon?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood clots: This medication may increase the risk of blood clots, especially if you are already at risk of blood clots. Risk factors for blood clots include being severely overweight and having a personal or family history of blood clots. However, pregnancy itself can also increase the risk of a blood clot.

Ectopic pregnancies: This medication may increase the risk of having an ectopic pregnancy (where the baby develops in one of the fallopian tubes instead of the uterus). It is important to have an early ultrasound to make sure that the baby is developing inside the uterus.

Multiple births: This medication may increase the risk of multiple births (mostly twins). Talk to your doctor about the risks of multiple births before beginning treatment.

Ovarian enlargement: Some women using this medication may experience ovarian enlargement associated with abdominal bloating or pain. In most cases, the pain and bloating stop without treatment within 2 or 3 weeks. If you experience these symptoms, contact your doctor.

Ovarian hyperstimulation syndrome (OHSS): Treatment with this medication can cause a condition called ovarian hyperstimulation syndrome (OHSS). With OHSS, too many follicles grow and cause abdominal or pelvic discomfort or pain, nausea, vomiting, and weight gain. Some women may experience difficulty breathing, diarrhea, and decreased urination. OHSS can progress rapidly and may become serious. It can occur even after treatment has stopped. If you experience any of these symptoms, contact your doctor immediately.

Pregnancy: This medication should not be used by pregnant women. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication should not be used by breast-feeding women.

Children: This medication is intended for use by people of child-bearing age. Its safety and effectiveness have not been established for children.

Seniors: This medication is intended for use by people of child-bearing age. Its safety and effectiveness have not been established for seniors.

What other drugs could interact with Puregon?

There may be an interaction between follitropin beta and any of the following:

  • buserelin
  • chorionic gonadotropin
  • clomiphene
  • follitropin alpha
  • gonadorelin acetate
  • goserelin
  • leuprolide
  • menotropins
  • nafarelin
  • urofollitropin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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