December 21, 2014
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Drug Factsheets

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Coversyl Plus

(perindopril - indapamide)

DIN (Drug Identification Number)

02246569 Coversyl Plus 1.25/4 mg Tablet
02246568 Coversyl Plus LD 0.625/2 mg Tablet
02321653 Coversyl Plus HD 2.5/8 mg Tablet

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Some people may have other risk factors for stroke. Talk to your doctor to find out if you're at risk of a stroke, and what you can do to reduce your risk.


To find out your risk of a stroke in the next 10 years, use the stroke risk assessment calculator.

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How does Coversyl Plus work? What will it do for me?

This combination product contains 2 medications: perindopril and indapamide. It is used to treat adults with mild to moderate high blood pressure.

Perindopril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It works by relaxing blood vessels and helping the heart to pump blood that carries oxygen to the different parts of the body more efficiently. Indapamide belongs to the class of medications called diuretics or "water pills," which help control blood pressure by getting rid of excess salt and water.

This combination medication is prescribed when your doctor feels it is appropriate for you to be taking both medications.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use Coversyl Plus?

This combination medication is used to make dosing more convenient for people who need to take both of these medications (perindopril and indapamide). The dose of the combination medication depends on the doses of the individual medications the person needs.

The usual recommended dose of this medication is one tablet taken once a day, preferably in the morning before a meal.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Coversyl Plus come in?

Coversyl Plus
Each white, rod-shaped tablet contains perindopril 4 mg and indapamide 1.25 mg. Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, hydrophobic colloidal silica, and magnesium stearate.

Coversyl Plus LD
Each white, rod-shaped, scored tablet contains perindopril erbumine 2 mg and indapamide 0.625 mg. Nonmedicinal ingredients: hydrophobic colloidal silica, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

Coversyl Plus HD
Each white, round tablet contains perindopril 8 mg and indapamide 2.5 mg. Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, hydrophobic colloidal silica, and magnesium stearate.

Who should NOT take Coversyl Plus?

Do not use perindopril - indapamide if you:

  • are allergic to perindopril, indapamide, or any ingredients of the medication
  • are allergic to sulfa (sulfonamide) medications (e.g., sulfamethoxazole)
  • are pregnant
  • are breast-feeding
  • have decreased kidney function or are unable to pass urine
  • have untreated high or low potassium
  • have had angioedema (a serious allergic reaction that causes the area around the throat and tongue to swell) after taking any ACE inhibitors (e.g., captopril, ramipril)
  • have diabetes or kidney disease and are taking aliskiren
  • have galactose intolerance (a rare hereditary disease)
  • have hereditary angioedema (a serious allergic reaction which causes swelling of the hands, feet, ankles, face, lips, tongue, or throat) or have angioedema with no known cause
  • have lactose intolerance
  • have severely decreased liver function or have hepatic encephalopathy
  • have untreated heart failure

This medication should not be given to anyone who is in a coma due to reduced liver function.

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