October 26, 2014
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Drug Factsheets

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Minirin

(desmopressin tablet)

DIN (Drug Identification Number)

02246500 MINIRIN 0.1MG TABLET

How does Minirin work? What will it do for me?

The tablet form of desmopressin belongs to the class of medications known as antidiuretics. It is a hormone taken by mouth to control excessive urination during the night (bedwetting). It is also used to treat central diabetes insipidus, a condition where the kidneys are unable to conserve water due to a lack of antidiuretic hormone (ADH). This condition causes frequent urination and thirst. This medication works by acting on the kidneys to reduce the amount of urine they produce. It usually starts to work within an hour and lasts for 7 to 9 hours.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Minirin?

For controlling excessive urination at night, the usual starting dose for oral tablets (i.e., taken by mouth and swallowed) is 0.2 mg to be taken one hour before bedtime. The usual starting dose for sublingual tablets (tablets that are placed under the tongue) is 120 µg taken one hour before bedtime. Depending on your response to this medication, your doctor may increase the dose up to 0.4 mg at bedtime for tablets or 360 µg at bedtime for sublingual tablets over several weeks. You should limit your fluid intake for a few hours before taking this medication. In addition, you should limit the amount of alcohol and caffeine you consume during evening hours.

For central diabetes insipidus, the usual starting dose for oral tablets is 0.1 mg 3 times daily. The usual starting dose for sublingual tablets is 60 µg 3 times daily. Your doctor will then adjust the dose depending on your response to this medication.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you are taking this medication for controlling excessive urination at night and you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

If you are taking this medication for central diabetes insipidus and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Minirin come in?

Each white, oval, uncoated tablet, marked with "0.1" on one side contains desmopressin acetate 0.1 mg. Nonmedicinal ingredients: lactose monohydrate, magnesium stearate, potato starch, and povidone.

Who should NOT take Minirin?

Desmopressin tablets should not be taken by anyone who:

  • is allergic to desmopressin or to any of the ingredients of the medication
  • has low blood sodium levels, severe liver disease, impaired kidney function, heart failure, or conditions leading to low sodium in the blood (e.g., bulimia, anoerxia nervosa, chronic vomiting, diarrhea, and adrenal impairment)
  • has type IIB or platelet type (pseudo) von Willebrand's disease

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