November 21, 2009
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PMS-Morphine Sulfate SR

(morphine sulfate sustained release)

DIN (Drug Identification Number)

02245284 PMS-MORPHINE SULFATE SR 15 MG
02245285 PMS-MORPHINE SULFATE SR 30 MG
02245286 PMS-MORPHINE SULFATE SR 60 MG

How does PMS-Morphine Sulfate SR work? What will it do for me?

Morphine belongs to the class of medications called narcotic analgesics (pain relievers). This medication is used to treat severe chronic pain. It acts on the brain to increase pain tolerance. This pain reliever should only be used when chronic pain control is necessary and should not be used to treat acute pain. Your doctor may prescribe additional pain relievers that act more quickly for treatment of acute or "breakthrough" pain.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

How should I use PMS-Morphine Sulfate SR?

The dose of long-acting morphine varies widely based on needs. Tablets or capsules are to be taken every 12 hours on a regular schedule in order to achieve pain relief. In order to preserve the long-acting activity of the medication, the tablets or capsules should not be chewed or crushed.

This medication may be habit forming if taken for long periods of time. You may experience withdrawal effects if you stop taking this medication suddenly after extended use. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important to take this medication exactly as prescribed by your doctor. Do not stop taking this medication without talking to your doctor first, and do not increase the dose of this medication without consulting your doctor. If you miss a dose, take it as soon as possible and continue on with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue on with your regular dosing schedule. Do not double doses.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does PMS-Morphine Sulfate SR come in?

15 mg
Each green, round, sustained-release, film-coated, biconvex tablet, imprinted with "P" logo on one side and "15 mg" on the other side, contains morphine sulfate 15 mg. Nonmedicinal ingredients: D&C Yellow No.10 Aluminum Lake, cetostearyl alcohol, FD&C Blue No.1 Aluminum Lake, FD&C Blue No.2, hydroxyethyl cellulose, lactose, magnesium stearate, methylcellulose, polyethylene glycol, talc and titanium dioxide.

30 mg
Each violet, round, sustained-release, film-coated, biconvex tablet, imprinted with "P" logo on one side and "30 mg" on the other side, contains morphine sulfate 30 mg. Nonmedicinal ingredients: cetostearyl alcohol, D&C Red No.7 calcium Lake, FD&C Blue No.1 Aluminum Lake, hydroxyethyl cellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, polysorbate, polyethylene glycol, talc and titanium dioxide.

60 mg
Each orange, round, sustained-release, film-coated, biconvex tablet, imprinted with "P" logo on one side and "60 mg" on the other side, contains morphine sulfate 60 mg. Nonmedicinal ingredients: cetostearyl alcohol, D&C Yellow No.10 Aluminum Lake, FD&C Yellow No.6 Aluminum Lake, FD&C Red No.3 Aluminum Lake, hydroxyethyl cellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, polyethylene glycol, talc and titanium dioxide.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take PMS-Morphine Sulfate SR?

This medication should not be taken by anyone with:

  • an allergy to narcotic analgesics or to any of the ingredients of the medication
  • acute asthma or other obstructive airway disease
  • acute respiratory depression
  • acute alcoholism or delirium tremens
  • severe cirrhosis
  • severe depression of the central nervous system (i.e., sedation)
  • cor pulmonale
  • abnormal heart rhythms
  • convulsive (seizure) disorders
  • head injury, brain tumour, or increased pressure inside the head or spinal cord
  • a medication regimen (current or completed in the last 14 days) that includes MAO inhibitors such as phenelzine or tranylcypromine
  • suspected abdominal conditions which may require surgery
  • surgical anastomosis
  • recent surgery of the biliary tract
  • severe low blood pressure

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