November 21, 2014
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Drug Factsheets

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Dukoral

(cholera and travellers' diarrhea vaccine (oral, inactivated))

DIN (Drug Identification Number)

02247208 DUKORAL SUSPENSION

What side effects are possible with Dukoral?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • diarrhea
  • nausea
  • vomiting

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a severe allergic reaction (difficulty breathing, hives, swelling of the mouth or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Dukoral?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: Rarely, this vaccine may cause severe allergic reactions. If you notice the signs of a severe allergic reaction (e.g., hives; trouble breathing or swallowing; or swelling of the lips, face, throat, or tongue), get emergency medical attention immediately.

Immunocompromised people: This vaccine may not be as effective for people with a compromised immune system (e.g., people with AIDS, people taking anti-rejection medications after an organ transplant, people receiving chemotherapy, people taking any medication that suppresses the immune system). People who have reduced immune function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Protection against cholera and travellers' diarrhea caused by ETEC: Not all people who take the vaccine will be fully protected against cholera and travellers' diarrhea caused by ETEC. This vaccine will not protect against diarrhea caused by other organisms. Travellers should take all necessary precautions to avoid contact with, or ingestion of, potentially contaminated sources of food or water (e.g., drink bottled or boiled water, wash hands before eating and after using toilet facilities).

Pregnancy: This vaccine should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using this vaccine, contact your doctor immediately.

Breast-feeding: This vaccine may be safely used while breast-feeding.

Children: The safety and effectiveness of using this vaccine have not been established for children 2 years of age and younger.

What other drugs could interact with Dukoral?

There may be an interaction between cholera and travellers' diarrhea vaccine and any of the following:

  • encapsulated oral typhoid vaccine (do not take within 8 hours of each other)
  • immunosuppressants (e.g., azathioprine, cyclosporine, prednisone, dexamethasone, etanercept, infliximab, tacrolimus, sirolimus)
  • other vaccines and medications taken by mouth (do not take other medications 1 hour before and 1 hour after this vaccine)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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