November 23, 2014
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Drug Factsheets

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Ezetrol

(ezetimibe)

DIN (Drug Identification Number)

02247521 EZETROL 10MG TABLET

What side effects are possible with Ezetrol?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • back pain
  • coughing
  • diarrhea
  • fatigue
  • headache
  • joint pain
  • red rash
  • sinus infections
  • throat infections

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • persistent muscle pain, aches or weakness, or brown urine
  • signs of gallbladder problems (such as sudden, severe abdominal pain, nausea, vomiting)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • symptoms of liver damage (such as yellow skin or eyes, dark urine, abdominal pain, severe fatigue, pale stools, or general itchiness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a severe allergic reaction (such as severe rash, swollen face, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Ezetrol?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: In rare cases, some people may develop an allergic reaction to this medication. Signs of an allergic reaction include a severe rash, swollen face, or difficulty breathing. If these occur, contact your doctor immediately.

Combination treatment: In some situations, this medication may be used in combination with another type of cholesterol-lowering medication called a "statin" (e.g., atorvastatin, pravastatin). If this combination is used, your liver function should be monitored by your doctor. This combination should not be used by pregnant women or people with active liver disease or unexplained, persistently abnormal tests of liver function.

Liver damage: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

This medication may cause liver damage. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Muscle pain or damage: This medication may cause muscle pain or damage. If you have unexpected muscle pain, weakness, or tenderness, see your doctor right away, especially if these symptoms do not seem to go away.

Pancreatitis (inflammation of the pancreas): This medication may cause the pancreas to become inflamed. This is called pancreatitis. If you have a history of or are at risk for developing pancreatitis, you should be closely monitored by your doctor while taking this medication. If you develop signs of pancreatitis (e.g., upper left abdominal pain, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen), contact your doctor. If you have a history of pancreatitis, gallstones, alcoholism, or high triglycerides, you may be more at risk of experiencing this. If you have sudden stomach or abdominal pains while taking this medication, contact your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if ezetimibe passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using ezetimibe have not been established for children under 10 years of age. Ezetimibe is not recommended for children less than 10 years of age.

What other drugs could interact with Ezetrol?

There may be an interaction between ezetimibe and any of the following:

  • cholestyramine
  • colestipol
  • cyclosporine
  • eltrombopag
  • fibrates (e.g., fenofibrate, gemfibrozil)
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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