December 20, 2014
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Drug Factsheets

 Health Home >> Medications 

Benadryl

(diphenhydramine (allergy))

DIN (Drug Identification Number)

02304252 BENADRYL ALLERGY LIQUIGELS 25MG
02019736 BENADRYL 12.5MG/5ML ELIXIR
02019701 BENADRYL CREAM 2%
02019671 BENADRYL CAPSULES 50MG
02061287 BENADRYL ALLERGY 12.5 MG CHEWABLE TABLETS
02019698 BENADRYL CHILDRENS LIQUID 6.25MG/5ML
02239138 BENADRYL EXTRA STRENGTH CAPLETS
02107849 BENADRYL 25MG CAPLETS

What side effects are possible with Benadryl?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • dry mouth
  • drowsiness
  • dizziness
  • excitation (especially in children)
  • nausea
  • nervousness
  • thickening of mucus

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision or any change in vision
  • confusion
  • difficult or painful urination

Stop taking this medication and seek immediate medical attention if any of the following occur:

  • symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the face, mouth, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Benadryl?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: This medication can cause drowsiness. Avoid driving or operating machinery until you have determined that this medication does not affect your ability to perform these tasks safely.

Medical conditions: If you have any of the following medical conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed:

  • children with chronic lung disease or glaucoma
  • enlarged prostate
  • narrow-angle glaucoma
  • peptic ulcer disease
  • obstructed bladder

Skin conditions: The topical cream should not be used on chickenpox, measles, or extensive areas of the skin. If the condition worsens or lasts for longer than 7 days, contact your doctor. Other medications containing diphenhydramine (e.g., tablets, capsules, liquids) should not be used while using the cream.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: The safety of using this medication while breast-feeding has not been established. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 2 years old.

Seniors: If you are a senior, this medication may be more likely to cause dizziness, drowsiness, and low blood pressure. Talk to your doctor or pharmacist before taking this medication.

What other drugs could interact with Benadryl?

There may be an interaction between diphenhydramine and any of the following:

  • alcohol
  • anticholinergics (e.g., benztropine, oxybutynin)
  • antihistamines (e.g., brompheniramine, chlorpheniramine)
  • barbiturates (e.g., phenobarbital, butalbital)
  • benzodiazepines (e.g., diazepam, lorazepam, oxazepam)
  • muscle relaxants (e.g., cyclobenzaprine)
  • opioid medications (e.g., codeine, morphine)
  • other medications that cause drowsiness (e.g., chlorpromazine, gabapentin, loxapine, mirtazapine, quetiapine, zopiclone, droperidol)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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