August 21, 2014
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Drug Factsheets

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Aclasta

(zoledronic acid)

DIN (Drug Identification Number)

02269198 ACLASTA IV

How does Aclasta work? What will it do for me?

Zoledronic acid belongs to the family of medications known as bisphosphonates. It is used to treat Paget's disease of the bone. It is also used to treat osteoporosis in men, to treat and prevent osteoporosis in postmenopausal women, and to treat and prevent osteoporosis caused by steroid medications.

Normally, the body maintains a balance between the processes of breaking down bone and building it up. In Paget's disease and osteoporosis, this balance becomes disturbed so that too much bone is being broken down. Zoledronic acid works by restoring the balance between the rate of bone breakdown and buildup.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop receiving this medication without consulting your doctor.

How should I use Aclasta?

For Paget's disease and for the prevention of osteoporosis in postmenopausal women, the recommended dose of zoledronic acid is 5 mg given as a one-time intravenous (into a vein) infusion.

For treatment of osteoporosis in men, and for treatment and prevention of osteoporosis caused by steroid medications, the recommended dose is 5 mg given as an intravenous (into a vein) infusion once a year. Infusions are given by a doctor or nurse over at least 15 minutes.

It is recommended that people taking this medication take calcium and vitamin D supplements to prevent low blood calcium levels. Your doctor will recommend a dose of these supplements based on your needs.

On the day of the infusion, it is important to drink at least 500 mL (2 cups) of fluids before and after the treatment.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.

It is important to receive this medication exactly as recommended by your doctor. If you miss an appointment to receive zoledronic acid, contact your doctor as soon as possible to reschedule your appointment.

This medication is stored at room temperature.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Aclasta come in?

Each bottle of ready-to-use sterile solution for intravenous infusion contains zoledronic acid 5 mg/100 mL monohydrate 5.330 mg (equivalent to 5 mg zoledronic acid on an anhydrous basis). Nonmedicinal ingredients: mannitol, sodium citrate, and water for injection. The colourless plastic bottle is sealed with a rubber stopper which is held in place with an aluminum cap with flip component. The stopper is made of bromobutyl rubber coated with fluorocarbon polymer and contains no latex.

Who should NOT take Aclasta?

Do not use zoledronic acid if you:

  • are allergic to zoledronic acid or any ingredient of this medication
  • are allergic to any other bisphosphonate medication (e.g., alendronate, etidronate)
  • are pregnant or breast-feeding
  • have decreased kidney function
  • have low blood calcium levels that have not been corrected

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