July 28, 2014
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Drug Factsheets

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Hyzaar

(losartan - hydrochlorothiazide)

DIN (Drug Identification Number)

02230047 HYZAAR 50/12.5MG TABLET
02297841 HYZAAR 100/12.5MG TABLET

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How does Hyzaar work? What will it do for me?

This is a combination product that contains 2 medications used to lower high blood pressure (hypertension), losartan and hydrochlorothiazide.

Losartan belongs to the class of medications called angiotensin II receptor blockers. They help to lower blood pressure by relaxing blood vessels. Hydrochlorothiazide belongs to the class of medications called diuretics or "water pills." It helps control blood pressure by getting rid of excess salt and water.

This combination medication is prescribed when your doctor feels it is appropriate for you to be taking both medications. It usually takes 3 to 6 weeks to see the full effects of this medication.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Hyzaar?

Once the dose of each medication (losartan and hydrochlorothizide) has been determined, the combination tablets can be started. The recommended dose is one tablet once daily. The maximum dose is one tablet per day.

The medication can be taken with or without food, but should be taken consistently. This means that if you usually take it with food, continue to take it with food, and if you usually take it without food, continue to take it without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Hyzaar come in?

50 mg/12.5 mg
Each yellow, oval-shaped, film-coated tablet, marked with code "717" on one side and plain on the other, contains losartan potassium 50 mg and hydrochlorothiazide 12.5 mg. Nonmedicinal ingredients: hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, quinoline yellow aluminum lake or D&C Yellow No. 10 Aluminum Lake, and titanium dioxide. May contain carnauba wax.

100 mg/12.5 mg
Each white to off-white, oval-shaped, film-coated tablet, with code "745" on one side and plain on the other, contains losartan potassium 100 mg and hydrochlorothiazide 12.5 mg. Nonmedicinal ingredients: hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and titanium dioxide. May contain carnauba wax.

Who should NOT take Hyzaar?

Do not take losartan - hydrochlorothiazide if you:

  • are allergic to losartan, hydrochlorothiazide, sulfa medications (e.g., sulfamethoxazole), or any ingredient of the medication
  • have anuria (are able to pass little or no urine)
  • are pregnant or breast-feeding

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