September 17, 2014
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RAN-Clarithromycin

(clarithromycin)

DIN (Drug Identification Number)

02361426 RAN-CLARITHROMYCIN 250MG TABLET
02361434 RAN-CLARITHROMYCIN 500MG TABLET

How does RAN-Clarithromycin work? What will it do for me?

Clarithromycin belongs to the group of medications called macrolide antibiotics. It is used to treat infections caused by certain bacteria. It works by killing or stopping the growth of bacteria that can cause certain infections. Clarithromycin may be prescribed for people with bacterial throat infections, sinus infections, ear infections, bronchitis, pneumonia, and skin infections such as impetigo and cellulitis.

Clarithromycin may also be used to prevent and treat certain infections (mycobacterium avium complex or MAC), associated with human immunodeficiency virus (HIV) infection. Clarithromycin can be used in combination with other medications to kill H. pylori, a bacteria known to cause ulcers in the digestive tract.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use RAN-Clarithromycin?

Adults: The recommended adult dosing of clarithromycin tablets is 250 mg to 500 mg twice daily (every 12 hours) for 7 to 14 days, depending on the condition being treated.

The recommended adult dosing of the extended release form of clarithromycin is 1,000 mg (2 tablets) once daily for 5 to 14 days, depending on the condition being treated.

For the treatment and prevention of MAC, the usual dose of clarithromycin is 500 mg twice daily. When used with other medications to kill H. pylori, the usual dose of clarithromycin is 500 mg twice daily for 10 days.

Children: The recommended total daily dose for children is 15 mg per kilogram of body weight (to a maximum of 1,000 mg per day). This total daily dose should be divided in 2 equal doses given 12 hours apart. Total treatment duration is usually 5 to 10 days, depending on the condition being treated. For the treatment and prevention of MAC, the usual dose of clarithromycin is 7.5 mg per kilogram of body weight twice daily (up to 500 mg twice daily).

If the child is receiving an oral suspension of clarithromycin, use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.

Clarithromycin tablets and clarithromycin suspension (given twice daily) may be taken with or without food. Taking this medication with food may cause less stomach upset.

The extended release tablets of clarithromycin must be taken with food. The tablets must be swallowed whole and not crushed or broken.

Finish all of this medication, even if you have started to feel better.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store clarithromycin tablets at room temperature, protect them from light and moisture, and keep them out of the reach of children.

Store clarithromycin oral suspension at room temperature with the bottle tightly closed and protected from light. Do not refrigerate. Any unused oral suspension should be thrown away after 14 days. Rinse the dose measuring oral syringe between uses. Do not store the suspension in the syringe.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does RAN-Clarithromycin come in?

250 mg
Each yellow, film-coated, oval-shaped, biconvex tablet debossed with "C1" on one side and plain on the other side, contains 250 mg of clarithromycin. Nonmedicinal ingredients: croscarmellose sodium, D&C Yellow No. 10 aluminum lake, hydroxypropyl cellulose, microcrystalline cellulose, hypromellose, magnesium stearate, povidone, propylene glycol, purified talc, colloidal anhydrous silica stearic acid, and titanium dioxide.

500 mg
Each light yellow, film-coated, oval-shaped, biconvex tablet debossed with "C2" on one side and plain on the other side, contains 500 mg of clarithromycin. Nonmedicinal ingredients: croscarmellose sodium, D&C Yellow No. 10 aluminum lake, hydroxypropyl cellulose, microcrystalline cellulose, hypromellose, magnesium stearate, povidone, propylene glycol, purified talc, colloidal anhydrous silica, stearic acid, and titanium dioxide.

Who should NOT take RAN-Clarithromycin?

Do not take clarithromycin if you:

  • are allergic to clarithromycin or any ingredients of this medication
  • are allergic to other macrolide antibiotics, such as erythromycin or azithromycin
  • are taking astemizole, terfenadine, cisapride, colchicine, pimozide, ergotamine, dihydroergotamine, lovastatin, or simvastatin or oral midazolam
  • are taking colchicine and also have reduced liver or kidney function
  • have had jaundice (yellowing of the skin or eyes) or liver problems associated with taking clarithromycin
  • have severe liver failure in addition to decreased kidney function
  • have or have had QT prolongation (an abnormal electrical activity of the heart) or an abnormal heart rhythm
  • have untreated hypokalemia (low potassium levels in the blood)

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