September 15, 2014
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Drug Factsheets

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RAN-Clarithromycin

(clarithromycin)

DIN (Drug Identification Number)

02361426 RAN-CLARITHROMYCIN 250MG TABLET
02361434 RAN-CLARITHROMYCIN 500MG TABLET

What side effects are possible with RAN-Clarithromycin?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • change in sense of taste
  • confusion
  • diarrhea (mild)
  • disorientation
  • dizziness
  • gas
  • headache
  • heartburn
  • nausea
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • severe abdominal or stomach cramps and pain
  • severe diarrhea
  • skin rash
  • symptoms of liver problems (e.g., abdominal tenderness, yellow eyes or skin, skin rash, itching, dark urine)
  • symptoms of myasthenia gravis (e.g., muscle weakness, drooping eyelid, vision changes)
  • watery and severe diarrhea, which may also be bloody

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • abnormal or irregular heartbeat
  • symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; sore throat; or swelling of the face, mouth, throat, or tongue)
  • symptoms of a severe skin reaction (e.g., peeling or blistering skin)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for RAN-Clarithromycin?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Abnormal heart rhythm: Clarithromycin may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, a medical condition associated with QT prolongation, or are taking certain medications (e.g., amiodarone, sotalol), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Allergy: If you have had some form of allergy to erythromycin or azithromycin, you may be more likely to have an allergic reaction to this medication. If you develop symptoms of an allergic reaction such as a rash, contact your doctor. If you develop hives; difficulty breathing; or swelling of the face, mouth, throat, or tongue, stop taking this medication and get immediate medical attention.

Diarrhea: As with other antibiotics, clarithromycin is associated with a serious infection called Clostridium difficile associated diarrhea, caused by the bacteria C. difficile. This can occur as late as 2 months after your last dose of this medication.

If you have loose, watery bowel movements especially if they are green, foul-smelling, or bloody and accompanied by fever, either during or after taking clarithromycin, get medical attention as soon as possible.

Dizziness, confusion, disorientation: This medication can cause dizziness, confusion, or disorientation. Do not drive or operate machinery until you are certain that this medication does not affect your ability to perform these tasks safely.

Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver problems: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you develop symptoms of liver problems (e.g., loss of appetite, nausea, vomiting, yellowing of the skin or eyes, dark urine, itchy skin, abdominal pain), contact your doctor immediately.

Myasthenia gravis: This medication can worsen or cause symptoms of myasthenia gravis. If your symptoms worsen or you develop new symptoms such as double vision, drooping eyelids, muscle weakness, or difficulty chewing or swallowing, contact your doctor.

Pregnancy: Clarithromycin should not be used during pregnancy, especially the first 3 months of pregnancy, unless there is no appropriate alternative therapy. If you become pregnant while taking this medication, contact your doctor.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking clarithromycin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using clarithromycin oral suspension have not been established for children younger than 6 months of age. For pneumonia, the use of clarithromycin oral suspension has not been studied for children younger than 3 years of age. The safety and effectiveness of using clarithromycin  to prevent MAC infection has not been studied for children under the age of 20 months. The safety and effectiveness of using clarithromycin tablets have not been established for children less than 12 years of age.

What other drugs could interact with RAN-Clarithromycin?

There may be an interaction between clarithromycin and any of the following:

  • alfentanil
  • almotriptan
  • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
  • alprazolam
  • amantadine
  • amiodarone
  • anti-emetic medications (serotonin antagonists; e.g., granisetron, ondansetron)
  • anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
  • apixaban
  • aprepitant
  • aripiprazole
  • astemizole
  • atazanavir
  • atorvastatin
  • axitinib
  • azithromycin
  • "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • BCG vaccine
  • benzodiazepines (e.g., clonazepam, diazepam, lorazepam)
  • bosentan
  • bosutinib
  • brinzolamide
  • bromocriptine
  • buprenorphine
  • buspirone
  • busulfan
  • calcitriol
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • carbamazepine
  • chloramphenicol
  • chloroquine
  • cimetidine
  • cinacalcet
  • cisapride
  • clopidogrel
  • colchicine
  • conivaptan
  • corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
  • nasal and inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
  • cyclosporine
  • dabigatran
  • dapsone
  • darunavir
  • dasatinib
  • deferasirox
  • desvenlafaxine
  • dexamethasone
  • diazepam
  • digoxin
  • disopyramide
  • divalproex
  • domperidone
  • doxazosin
  • doxorubicin
  • dronedarone
  • eletriptan
  • enzalutamide
  • eplerenone
  • ergot alkaloids (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
  • erlotinib
  • erythromycin
  • estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol, norethindrone)
  • etravirine
  • everolimus
  • felbamate
  • fentanyl
  • flutamide
  • gadobutrol
  • guanfacine
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
  • imatinib
  • insulin
  • isosorbide dinitrate
  • lidocaine
  • losartan
  • maraviroc
  • medications used to treat diabetes (e.g., pioglitazone, rosiglitazone, repaglinide)
  • midazolam
  • modafinil
  • montelukast
  • nefazodone
  • nilotinib
  • norfloxacin
  • ondansetron
  • oxcarbazepine
  • oxtriphylline
  • paliperidone
  • pazopanib
  • phenobarbital
  • phenytoin
  • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • pimozide
  • prasugrel
  • praziquantel
  • procainamide
  • progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)
  • propafenone
  • proton pump inhibitors (e.g., lansoprazole, omeprazole)
  • quinidine
  • quinine
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • regorafenib
  • rifabutin
  • rifampin
  • rivaroxaban
  • romidepsin
  • salmeterol
  • silodosin
  • sirolimus
  • SSRIs (e.g., fluoxetine, paroxetine, sertraline)
  • St. John's wort
  • "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • tacrolimus
  • tamoxifen
  • tamsulosin
  • temsirolimus
  • terfenadine
  • tetrabenazine
  • tetracycline
  • theophylline
  • ticagrelor
  • ticlopidine
  • tolterodine
  • topotecan
  • tramadol
  • trazodone
  • trimethoprim
  • typhoid vaccine
  • ulipristal
  • valproic acid
  • vandetanib
  • vemurafenib
  • venlafaxine
  • vincristine
  • vinblastine
  • warfarin
  • zidovudine
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than the ones listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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