August 30, 2014
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Drug Factsheets

 Health Home >> Medications 

Neulasta

(pegfilgrastim)

DIN (Drug Identification Number)

02249790 NEULASTA 10MG / ML SUBCUTANEOUS SOLUTION

What side effects are possible with Neulasta?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • bone pain

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • chest pain

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • a severe allergic reaction (e.g., hives, shortness of breath, wheezing, swelling of the face or throat, fast heart rate, dizziness)
  • signs of a ruptured spleen (e.g., upper left abdominal pain or pain at the tip of the shoulder pain)
  • signs of acute respiratory distress syndrome (e.g., fever, shortness of breath, cough, or lung congestion)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Neulasta?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

April 10, 2014

Health Canada has issued new restrictions concerning the use of Neulasta (pegfilgrastim). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Cytotoxic chemotherapy: The safety of using pegfilgrastim at the same time as cytotoxic chemotherapy (a type of chemotherapy that kills cells, especially cancer cells) has not been established. Pegfilgrastim should not be used within 14 days before or 24 hours after chemotherapy. In addition, it is not known whether is is safe and effective to use pegfilgrastim after certain chemotherapy medications (e.g., mitomycin C, 5-flurouracil, and nitrosoureas such as carmustine and lomustine).

Lung problems: Pegfilgrastim may cause adult respiratory distress syndrome (ARDS), a serious lung condition, when people with neutropenia have sepsis (bacterial infection in the blood). If ARDS occurs, this medication should be stopped until the ARDS resolves.

Radiation: It is nnot known whether it is safe and effective to use pegfilgrastim with radiation therapy. Pegfilgrastim should not be used during radiation therapy.

Sickle cell disease: Pegfilgrastim may cause sickle cell crisis when used by people who have sickle cell disease. You and your doctor should carefully consider the benefits and risks of using pegfilgrastim in these circumstances.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, stop taking it immediately and call your doctor.

Breast-feeding: It is not known whether pegfilgrastim passes into breast milk. Pegfilgrastim is not recommended by breast-feeding mothers.

Children: The safety and effectiveness of pegfilgrastim have not been established for children.

What other drugs could interact with Neulasta?

There may be an interaction between pegfilgrastim and any of the following:

  • 5-flurouracil
  • carmustine
  • lithium
  • lomustine
  • mitomycin C
  • other cytokine medications (e.g., growth factors)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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