April 18, 2014
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Drug Factsheets

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Losec

(omeprazole)

DIN (Drug Identification Number)

02119579 LOSEC 10MG CAPSULE
02230737 LOSEC 10MG TABLET
00846503 LOSEC 20MG CAPSULE
02190915 LOSEC 20MG TABLET

What side effects are possible with Losec?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal or stomach pain
  • constipation
  • diarrhea or loose stools
  • dizziness
  • gas
  • headache

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • changes in vision
  • fever or chills
  • flu-like symptoms
  • mild skin rash or itching
  • muscle aches or cramps
  • pain or burning in the mouth or throat
  • signs of liver damage (yellow skin or eyes, dark urine, loss of appetite, abdominal pain, fever, and fatigue)
  • swelling of the hands or feet (if there is no shortness of breath)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • redness, tenderness, itching, burning, or peeling of skin
  • signs of an allergic reaction (e.g., difficulty breathing, hives, swelling of the face or throat)
  • signs of bleeding (e.g., easy bruising, bleeding gums, nosebleeds, vomiting blood, blood in the urine, dark tarry stools)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Losec?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

April 4, 2013

Health Canada has issued new information concerning the use of omeprazole. To read the full report, visit Health Canada's website at www.hc-sc.gc.ca.

Previous advisories on omeprazole were issued on February 16, 2012 and October 19, 2012.

To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Liver disease: People with severe liver disease should generally not take more than 20 mg of omeprazole daily.

Severe stomach problems: If you have recurrent vomiting, difficulty swallowing, blood in the stool, coughing up of blood, or significant unintentional weight loss, check with your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, call your doctor immediately.

Breast-feeding: It is not known if omeprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Using the same dosage, seniors reach higher blood levels of omeprazole than younger people. Therefore, seniors may need to take reduced doses and should generally not take more than 20 mg of omeprazole daily.

What other drugs could interact with Losec?

There may be an interaction between omeprazole and any of the following:

  • antipyrine
  • atazanavir
  • citalopram
  • clopidogrel
  • dasatinib
  • delavirdine
  • diazepam
  • fluconazole
  • itraconazole
  • ketoconazole
  • methotrexate
  • nelfinavir
  • phenytoin
  • tacrolimus
  • ticlopdine
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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