October 26, 2014
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Drug Factsheets

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Apo-Metoclop

(metoclopramide)

DIN (Drug Identification Number)

00842834 APO-METOCLOP 10MG TABLET
00842826 APO-METOCLOP 5MG TABLET

What side effects are possible with Apo-Metoclop?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • diarrhea (with high doses)
  • dizziness
  • drowsiness
  • restlessness or difficulty sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • chills
  • difficulty speaking or swallowing
  • dizziness or fainting
  • fast or irregular heartbeat
  • fever
  • general feeling of tiredness or weakness
  • headache (severe or continuing)
  • inability to move eyes
  • increase in blood pressure
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • muscle spasms of face, neck, and back
  • puffing of cheeks
  • rapid or worm-like movements of tongue
  • shuffling walk
  • sore throat
  • stiffness of arms or legs
  • tic-like or twitching movements
  • trembling and shaking of hands and fingers
  • twisting movements of body
  • uncontrolled chewing movements
  • uncontrolled movements of arms and legs
  • weakness of arms and legs

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Apo-Metoclop?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

July 20, 2011

Health Canada has issued new information concerning the use of metoclopramide. To read the full report, visit Health Canada's web site at www.hc-sc.gc.ca.

Drowsiness/reduced alertness : Metoclopramide may cause drowsiness and increase the drowsiness caused by alcohol and other drugs. Avoid driving and doing other potentially hazardous activities until you have determined the effect this medication has on you.

Medical conditions: If you have epilepsy, Parkinson's disease, or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking metoclopramide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The total daily dose for children should not be higher than 0.5 mg per kilogram of body weight since with higher doses tremors and abnormal twitching movements can occur.

Seniors: Seniors appear to have a higher risk of side effects with long-term treatment of metoclopramide.

What other drugs could interact with Apo-Metoclop?

There may be an interaction between metoclopramide and any of the following:

  • anticholinergic medications (e.g., scopolamine, tolterodine)
  • antipsychotic medications (e.g., haloperidol, ziprasidone)
  • cyclosporine
  • droperidol
  • levodopa
  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • medications that cause drowsiness (e.g., sedatives such as lorazepam)
  • narcotic medications (e.g., codeine, morphine)
  • succinylcholine
  • tetrabenazine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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