November 28, 2014
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Drug Factsheets

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Sinequan

(doxepin)

DIN (Drug Identification Number)

00326925 SINEQUAN 100MG CAPSULE
00024325 SINEQUAN 10MG CAPSULE
00024333 SINEQUAN 25MG CAPSULE
00024341 SINEQUAN 50MG CAPSULE
00400750 SINEQUAN 75MG CAPSULE

How does Sinequan work? What will it do for me?

Doxepin belongs to the family of medications known as tricyclic antidepressants. It is used to treat depression, especially when anxiety is one of the symptoms.

Doxepin is also used to treat people with alcoholism who also have anxiety or depression. Tricyclic antidepressants are believed to work by keeping the balance of natural chemicals (neurotransmitters) in the body, namely serotonin and norepinephrine.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

Learn more about related conditions:

These conditions are related to the conditions the drug is approved to treat. The drug may not be approved to treat all of the conditions listed here.

How should I use Sinequan?

The recommended adult daily dose of doxepin ranges from 75 mg to 300 mg in 3 divided doses. The usual starting dose is 25 mg 3 times daily. The total dose can be taken at bedtime once the final dose is reached (as long as the final dose is 150 mg per day or less). Lower doses may be needed for seniors.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Sinequan come in?

10 mg
Each pink and scarlet capsule contains doxepin 10 mg. Nonmedicinal ingredients: cornstarch, magnesium stearate, and sodium lauryl sulfate; capsule shell: D&C Yellow No. 10, FD&C Blue No. 1 FD&C Red No. 2, FD&C Red No. 3, FD&C Yellow No. 6, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

25 mg
Each pink and blue capsule contains doxepin 25 mg. Nonmedicinal ingredients: cornstarch, magnesium stearate, and sodium lauryl sulfate; capsule shell: FD&C Blue No. 1, FD&C Red No. 3, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

50 mg
Each flesh-coloured and pink capsule contains doxepin 50 mg. Nonmedicinal ingredients: cornstarch, magnesium stearate, and sodium lauryl sulfate; capsule shell: D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 3, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

75 mg
Each flesh-coloured capsule contains doxepin 75 mg. Nonmedicinal ingredients: cornstarch, magnesium stearate, and sodium lauryl sulfate; capsule shell: D&C Yellow No. 10, FD&C Red No. 3, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

100 mg
Each flesh-coloured and blue capsule contains doxepin 100 mg. Nonmedicinal ingredients: cornstarch, magnesium stearate, and sodium lauryl sulfate; capsule shell: D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 3, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

Who should NOT take Sinequan?

Doxepin should not be taken by anyone who:

  • is allergic to doxepin or to any of the ingredients of the medication
  • is allergic to any other dibenzoxepin compounds
  • is a child
  • has acute congestive heart failure
  • has blood disorders
  • has glaucoma or increased eye pressure
  • has just had a heart attack
  • has severe liver disease
  • has taken a MAO inhibitor (e.g., phenelzine, tranylcypromine) within the last 14 days
  • has urinary retention

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Depression Symptom Checker Tool

The Depression Symptom Checker tool can help you learn about depression. Use this tool to create a list of your symptoms and rate how much the symptoms impact your life on a daily basis. The checklist is divided into 6 symptom categories that are associated with depression. You can also learn more about symptoms of depression here.

For each statement choose a number from 0 to 4 that describes the impact on your daily life, where 4 has the highest impact and 0 has no impact:

  • 0 = no impact on daily life/no symptoms
  • 1 = mild impact on daily life
  • 2 = moderate impact on daily life
  • 3 = severe impact on daily life
  • 4 = debilitating impact on daily life

It is important to remember that this is not a “score” but a way to help you communicate how much you feel the symptom impacts your daily life. When you finish you will be able to print out your symptoms and share this information with your doctor. Use the Doctor Discussion Guide to prepare for your doctor’s visit.

Rate how much the following symptoms apply to you.

1. Emotions

Depression can affect anyone at any age, although it most commonly appears between 15 and 45 years of age.

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Visit your doctor with these results, when booking your appointment inform your doctor that you may need extra time to discuss these matters. Getting help for your depression can change your life. Don’t wait- depression is an illness that can, and should be treated.

Thoughts about death or suicide are common in depression, and it’s important to take such thoughts seriously. If you feel like giving up or as if you might hurt yourself, get help immediately: call your doctor, go to the emergency room or call 911.

This tool is adapted with permission from similar content found on www.depressionhurts.ca.


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