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Apo-Doxepin

(doxepin HCl)

In this factsheet:
• How does Apo-Doxepin work? What will it do for me?
• How should I use Apo-Doxepin?
• What form(s) does Apo-Doxepin come in?
• Who should NOT take Apo-Doxepin?
• What side effects are possible with Apo-Doxepin?
• Are there any other precautions or warnings for Apo-Doxepin?
• What other drugs could interact with Apo-Doxepin?

DIN (Drug Identification Number)

How does Apo-Doxepin work? What will it do for me?

Doxepin belongs to the family of medications known as tricyclic antidepressants. It is used to treat depression, especially when anxiety is one of the symptoms. Doxepin is also used to treat people with alcoholism who also have anxiety or depression.

Tricyclic antidepressants work by increasing the amount of norepinephrine and serotonin neurotransmitters available in certain parts of the brain.

Your doctor may choose to use a medication for conditions other than the ones listed in these drug information articles. If you're unsure why you are taking this medication, contact your doctor.

How should I use Apo-Doxepin?

The recommended adult daily dose of doxepin ranges from 75 mg to 300 mg in three divided doses. The usual starting dose is 25 mg three times daily. The total dose can be taken at bedtime once the final dose is reached. Lower doses may be used by seniors.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by the doctor. If you miss a dose, take it as soon as possible and continue on with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue on with your regular dosing schedule. Do not double doses.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does Apo-Doxepin come in?

10 mg
Each No. 4, pink and scarlet capsule, identified "APO 10", contains doxepin HCl equivalent to doxepin base 10 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: EEC amaranth, D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, FD&C Yellow No. 6, gelatin and titanium dioxide.

25 mg
Each No. 4, pink and blue capsule, identified "APO 25", contains doxepin HCl equivalent to doxepin base 25 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

50 mg
Each No. 2, flesh and pink capsule, identified "APO 50", contains doxepin HCl equivalent to doxepin base 50 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

75 mg
Each No. 2, flesh - coloured capsule, identified "APO 75", contains doxepin HCl equivalent to doxepin base 75 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

100 mg
Each No. 1, flesh and blue capsule, identified "APO 100", contains doxepin HCl equivalent to doxepin base 100 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, gelatin, sodium lauryl sulfate, silicon dioxide and titanium dioxide.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take Apo-Doxepin?

Doxepin should not be taken by anyone who:

• is allergic to doxepin or any of the ingredients of the medication or any other dibenzoxepin compounds
• has glaucoma or increased eye pressure
• has urinary retention
• has just had a heart attack
• has acute congestive heart failure
• has blood disorders
• has severe liver disease
• has taken a MAO inhibitor (e.g., phenelzine, tranylcypromine) within the last 14 days
• is a child

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