December 21, 2014
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Drug Factsheets

 Health Home >> Medications 

Trimipramine

(trimipramine)

DIN (Drug Identification Number)

00740829 TRIMIPRAMINE 100MG TABLET
00740799 TRIMIPRAMINE 12.5MG TABLET
00740802 TRIMIPRAMINE 25MG TABLET
00740810 TRIMIPRAMINE 50MG TABLET
02070987 TRIMIPRAMINE 75MG CAPSULE

What side effects are possible with Trimipramine?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • diarrhea
  • dizziness
  • drowsiness
  • dryness of mouth
  • headache
  • heartburn
  • increased appetite (may include a craving for sweets)
  • increased sweating
  • nausea
  • tiredness or weakness (mild)
  • trouble sleeping
  • unpleasant taste
  • vomiting
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common:

  • blurred vision
  • confusion or delirium
  • constipation (especially for seniors)
  • decreased sexual ability
  • difficulty speaking or swallowing
  • eye pain
  • fainting
  • fast or irregular heartbeat (pounding, racing, skipping)
  • hallucinations
 
  • loss of balance control
  • mask-like face
  • nervousness or restlessness
  • numbness or tingling sensation in arms and legs
  • problems urinating
  • shakiness or trembling
  • shuffling walk
  • slowed movements
  • stiffness of arms and legs

Rare:

  • anxiety
  • breast enlargement (both males and females)
  • hair loss
  • inappropriate secretion of milk (females)
  • increased sensitivity to sunlight
  • irritability
  • muscle twitching
  • red or brownish spots on skin
  • ringing, buzzing, or other unexplained sounds in the ears
  • seizures
  • skin rash and itching
  • sore throat and fever
  • swelling of face and tongue
  • swelling of testicles
  • trouble with teeth or gums
  • weakness
  • yellow eyes or skin

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Trimipramine?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Alcohol: Your response to alcoholic beverages may be affected while taking this medication.

Constipation: Trimipramine may cause constipation, especially for seniors.

Medical conditions: Trimipramine should be used with caution by people with a history of seizures, urinary retention, glaucoma, or thyroid disease. Tricyclic antidepressant medications such as trimipramine, particularly when taken in high doses, can cause abnormal heart rhythms. Therefore, trimipramine should be taken with caution by seniors or people with a history of heart disease.

Mental and physical impairment: Trimipramine may impair the mental or physical abilities required for the performance of potentially hazardous tasks, such as driving or operating machinery.

Withdrawal: Stopping treatment with trimipramine after having taken it for a long period of time may produce nausea, headache, and malaise. These symptoms do not mean that you are addicted to the medication. Do not stop taking trimipramine suddenly without first talking with your doctor.

Pregnancy: The safety of trimipramine for use during pregnancy has not been established. If you are or may be pregnant, the possible benefits of taking this medication must be weighed against the possible risks. If you are or may be pregnant, talk to your doctor.

Breast-feeding: The safety of trimipramine for use while breast-feeding has not been established. If you are breast-feeding, the possible benefits of taking this medication must be weighed against the possible risks to the child. If you are breast-feeding, talk to your doctor.

What other drugs could interact with Trimipramine?

There may be an interaction between trimipramine and any of the following:

  • alcohol
  • amphetamines (e.g., dextroamphetamine)
  • anticholinergic medications (e.g., benztropine, atropine)
  • appetite suppressants (e.g., mazindol, phentermine)
  • barbiturates (e.g., phenobarbital, secobarbital)
  • benzodiazepines (e.g., diazepam, lorazepam)
  • cimetidine
  • cisapride
  • clonidine
  • divalproex sodium
  • fluoxetine
  • fluvoxamine
  • guanethidine
  • MAO inhibitors (e.g., tranylcypromine, phenelzine)
  • rifabutin
  • rifampin
  • sertraline
  • sympathomimetic medications (e.g., dopamine, epinephrine)
  • valproic acid

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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Depression Symptom Checker Tool

The Depression Symptom Checker tool can help you learn about depression. Use this tool to create a list of your symptoms and rate how much the symptoms impact your life on a daily basis. The checklist is divided into 6 symptom categories that are associated with depression. You can also learn more about symptoms of depression here.

For each statement choose a number from 0 to 4 that describes the impact on your daily life, where 4 has the highest impact and 0 has no impact:

  • 0 = no impact on daily life/no symptoms
  • 1 = mild impact on daily life
  • 2 = moderate impact on daily life
  • 3 = severe impact on daily life
  • 4 = debilitating impact on daily life

It is important to remember that this is not a “score” but a way to help you communicate how much you feel the symptom impacts your daily life. When you finish you will be able to print out your symptoms and share this information with your doctor. Use the Doctor Discussion Guide to prepare for your doctor’s visit.

Rate how much the following symptoms apply to you.

1. Emotions

Depression can affect anyone at any age, although it most commonly appears between 15 and 45 years of age.

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No Impact
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Mild
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0
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No Impact
Mild
Moderate
Severe
Debilitating
0
1
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No Impact
Mild
Moderate
Severe
Debilitating

Visit your doctor with these results, when booking your appointment inform your doctor that you may need extra time to discuss these matters. Getting help for your depression can change your life. Don’t wait- depression is an illness that can, and should be treated.

Thoughts about death or suicide are common in depression, and it’s important to take such thoughts seriously. If you feel like giving up or as if you might hurt yourself, get help immediately: call your doctor, go to the emergency room or call 911.

This tool is adapted with permission from similar content found on www.depressionhurts.ca.


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