September 22, 2014
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Drug Factsheets

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Cardizem CD

(diltiazem)

DIN (Drug Identification Number)

02097249 CARDIZEM CD 120MG CAPSULE
02097257 CARDIZEM CD 180MG CAPSULE
02097265 CARDIZEM CD 240MG CAPSULE
02097273 CARDIZEM CD 300MG CAPSULE

What side effects are possible with Cardizem CD?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • diarrhea
  • dizziness or lightheadedness
  • flushing
  • headache
  • heartburn
  • nausea
  • nervousness
  • tiredness or weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • breathing difficulty, coughing, or wheezing
  • fainting
  • irregular or fast, pounding heartbeat
  • skin rash
  • slow heartbeat (less than 50 beats per minute)
  • swelling of ankles, feet, or lower legs
  • vomiting

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Cardizem CD?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood pressure: Diltiazem may lower blood pressure too much in certain cases. If you experience lightheadedness, weakness, or dizziness, talk to your doctor.

Congestive heart failure: If you have congestive heart failure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Diabetes: Diltiazem may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Heart rhythm problems: In people with certain types of heart rhythm problems (sick sinus syndrome, second- and third-degree atrio-ventricular block) who do not have pacemakers, diltiazem may cause abnormally slow heart rates. People with certain types of heart rhythm problems should not take diltiazem. If you have a heart rhythm problem, your doctor should closely monitor your condition while you are taking diltiazem. Talk to your doctor if you have any concerns.

Kidney function: The kidneys are partially responsible for removing diltiazem from the body. As a result, kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

Rarely, diltiazem may cause liver damage. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: Women who are or may become pregnant should not take diltiazem. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Diltiazem passes into breast milk. If you are a breast-feeding mother and are taking diltiazem, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of diltiazem for use by children have not been established.

What other drugs could interact with Cardizem CD?

There may be an interaction between diltiazem and any of the following:

  • aliskiren
  • alpha blockers (e.g., alfuzosin, doxazosin, silodosin, tamsulosin)
  • amiodarone
  • amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
  • anaesthetics
  • angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)
  • angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
  • anti-cancer medications (e.g., cabazitaxel, docetaxel; doxorubicin; etoposide, ifosfamide, irinotecan, vincristine)
  • aprepitant
  • aripiprazole
  • "azole" antifungals (e.g., fluconazole, ketoconazole, itraconazole)
  • barbiturates (e.g., butalbital, phenobarbital)
  • benzodiazepines (e.g., chlordiazepoxide, clonazepam, diazepam, lorazepam)
  • beta-adrenergic blocking agents (e.g., atenolol, labetalol, metoprolol)
  • bocepravir
  • bosutinib
  • buprenorphine
  • buspirone
  • busulfan
  • calcitriol
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • calcium supplements (e.g., calcium carbonate, calcium citrate)
  • carbamazepine
  • carvedilol
  • chloroquine
  • cimetidine
  • ciprofloxacin
  • clonidine
  • clopidogrel
  • conivaptan
  • oral corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
  • cyclosporine
  • dabrafenib
  • dantrolene
  • dapsone
  • dasatinib
  • deferasirox
  • digoxin
  • disopyramide
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
  • erlotinib
  • estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
  • ethosuximide
  • everolimus
  • felbamate
  • flecainide
  • flutamide
  • "gliptin" diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
  • grapefruit juice
  • guanfacine
  • haloperidol
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • imatinib
  • lidocaine
  • lithium
  • lomitapide
  • losartan
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • maraviroc
  • mefloquine
  • mestranol
  • methadone
  • methylphenidate
  • metronidazole
  • mifepristone
  • mirtazapine
  • modafinil
  • monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, tranylcypromine)
  • montelukast
  • nateglinide
  • nefazodone
  • nilotinib
  • nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
  • ondansetron
  • oxcarbazepine
  • oxycodone
  • pazopanib
  • pentoxifylline
  • perampanel
  • phenytoin
  • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • pimozide
  • praziquantel
  • primaquine
  • primidone
  • procainamide
  • progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)
  • propafenone
  • proton pump inhibitors (e.g., lansoprazole, omeprazole)
  • quetiapine
  • quinidine
  • quinine
  • ranitidine
  • repaglinide
  • rifabutin
  • rifampin
  • rilpivirine
  • rituximab
  • rivaroxaban
  • romidepsin
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • sirolimus
  • "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • St. John's wort
  • tacrolimus
  • tamoxifen
  • temsirolimus
  • teniposide
  • tetracycline
  • theophylline
  • ticagrelor
  • ticlopidine
  • tolterodine
  • tolvaptan
  • trabectedin
  • tramadol
  • trazodone
  • tricyclic antidepressasnts (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • trimethoprim
  • ulipristal
  • venlafaxine
  • warfarin
  • zolpidem
  • zonisamide
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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