October 25, 2014
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Drug Factsheets

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Apo-Bisoprolol

(bisoprolol)

DIN (Drug Identification Number)

02256177 APO-BISOPROLOL 10MG TABLET
02256134 APO-BISOPROLOL 5MG TABLET

What side effects are possible with Apo-Bisoprolol?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • cough
  • diarrhea
  • fatigue
  • headache
  • insomnia
  • joint pain
  • nausea
  • sore throat

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur.

  • dizziness
  • peripheral edema (swelling of the ankles)
  • rhinitis or sinusitis (inflammation in the nose)
  • urinary tract infection (painful urination, frequent urination, or cloudy urine)
  • very slow heart rate (less than 50 beats per minute)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a serious allergic reaction (e.g., hives, swelling of face or throat, difficulty breathing, rash, or itching)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Apo-Bisoprolol?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Angina: People with coronary artery disease may experience worsening of angina (chest pain) if they stop taking bisoprolol suddenly. If you want to stop taking the medication, talk to your doctor about how to do this safely by gradually reducing the dose over time.

Lung, heart, or circulation problems: If you have circulation problems, asthma, bronchitis, any other lung disease, or a history of heart failure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Hyperthyroidism: Bisprolol may mask the signs of thyroid overactivity. If it is stopped suddenly, it may cause a worsening of the symptoms of hyperthyroidism (overactive thyroid). Do not stop the medication on your own. Instead, talk to your doctor about how to safely stop the medication by gradually reducing the dose over time.

Diabetes: Bisoprolol may mask some symptoms of low blood sugar. If you have diabetes, your doctor should closely monitor your condition while you are taking bisoprolol.

Impaired kidney or liver function: Your doctor may recommend laboratory tests to check your kidney and liver function while you are on this medication.

Occupational hazards: Bisoprolol may cause drowsiness and lightheadedness. Avoid anything that requires you to be awake and alert until you know how the medication affects you.

Stopping the medication: Do not stop taking bisoprolol suddenly - check with your doctor first. Your doctor can advise you on how to stop the medication safely.

Surgery: Before surgery (including dental surgery), tell the doctor or dentist that you are taking bisoprolol.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if bisoprolol passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with Apo-Bisoprolol?

There may be an interaction between bisoprolol and any of the following:

  • aminophylline
  • asthma medications (e.g., theophylline)
  • diabetes medications (e.g., glyburide)
  • caffeine
  • calcium channel blocker medicines (e.g., diltiazem, felodipine, nifedipine, verapamil)
  • clonidine
  • cocaine
  • diltiazem
  • disopyramide
  • guanethidine
  • medications for abnormal heart rhythms (e.g., disopyramide)
  • methacholine
  • monoamine oxidase (MAO) inhibitors (e.g., phenelzine, selegiline, tranylcypromine)
  • other beta-blockers (e.g., propranolol, metoprolol)
  • oxtriphylline
  • reserpine
  • rifampin
  • verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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