October 22, 2014
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Drug Factsheets

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Apo-Mirtazapine

(mirtazapine)

DIN (Drug Identification Number)

02286610 Apo-Mirtazapine 15 mg Tablet
02286629 Apo-Mirtazapine 30 mg Tablet
02286637 Apo-Mirtazapine 45 mg Tablet

How does Apo-Mirtazapine work? What will it do for me?

Mirtazapine belongs to the group of medications known as tetracyclic antidepressants. Antidepressants are used to help relieve the symptoms of depression such as feeling low, sleeping problems, loss of appetite, and loss of interest in activities that you would normally enjoy doing.

When you have depression, certain chemicals in the brain are out of their normal balance. Antidepressants such as mirtazapine work by helping to bring the chemicals back into balance. Antidepressants usually take at least a few weeks to achieve their beneficial effect, so it is important to have patience and take the medication exactly as prescribed by your doctor.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Apo-Mirtazapine?

The recommended starting dose of mirtazapine for adults is 15 mg taken once daily in the evening before going to bed. The doctor may increase the dose to 30 mg after 1 to 2 weeks, depending on circumstances. The maximum recommended dose of mirtazapine is 45 mg daily. Swallow the tablets whole with water. Do not chew the tablets.

If you are taking the orally disintegrating tablet form of mirtazapine, it is important to handle these tablets properly.

The orally-disintegrating tablets have been designed to rapidly dissolve on the tongue and can be swallowed with saliva. Ensure that your hands are dry when you remove the tablet from its blister packaging, and then immediately place the tablet on your tongue. Note that tablets must be used immediately after removal from packaging. The tablets cannot be stored once they are removed from their packaging.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is normal to not feel any difference for the first 2 to 4 weeks of taking this medication. If you have side effects from this medication, talk with your doctor or pharmacist before stopping it.

It is important to take this medication exactly as prescribed by your doctor. If you miss your evening dose, do not take the missed dose the next morning. Skip the missed dose and continue with your regular dosing schedule in the evening. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Apo-Mirtazapine come in?

15 mg
Each light yellow, oval, film-coated scored tablet, imprinted "MI" bisect "15" on one side and "APO" on the other side, contains mirtazapine 15 mg. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, titanium dioxide, and yellow iron oxide.

30 mg
Each light pink, oval, film-coated scored tablet, imprinted "MI" bisect "30" on one side and "APO" on the other side, contains mirtazapine 30 mg. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, titanium dioxide, yellow iron oxide, and red iron oxide.

45 mg
Each white to off-white, oval, film-coated tablet with "MI-45" embossed on one side and "APO" on the other side, contains mirtazapine 45 mg. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, and titanium dioxide.


Who should NOT take Apo-Mirtazapine?

Do not take mirtazapine if you:

  • are allergic to mirtazapine or any ingredients of the medication
  • have taken any MAO inhibitors (e.g., phenelzine, tranylcypromine) in the previous 2 weeks
  • have hereditary galactose intolerance or glucose-galactose malabsorption

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Depression Symptom Checker Tool

The Depression Symptom Checker tool can help you learn about depression. Use this tool to create a list of your symptoms and rate how much the symptoms impact your life on a daily basis. The checklist is divided into 6 symptom categories that are associated with depression. You can also learn more about symptoms of depression here.

For each statement choose a number from 0 to 4 that describes the impact on your daily life, where 4 has the highest impact and 0 has no impact:

  • 0 = no impact on daily life/no symptoms
  • 1 = mild impact on daily life
  • 2 = moderate impact on daily life
  • 3 = severe impact on daily life
  • 4 = debilitating impact on daily life

It is important to remember that this is not a “score” but a way to help you communicate how much you feel the symptom impacts your daily life. When you finish you will be able to print out your symptoms and share this information with your doctor. Use the Doctor Discussion Guide to prepare for your doctor’s visit.

Rate how much the following symptoms apply to you.

1. Emotions

Depression can affect anyone at any age, although it most commonly appears between 15 and 45 years of age.

0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4

Visit your doctor with these results, when booking your appointment inform your doctor that you may need extra time to discuss these matters. Getting help for your depression can change your life. Don’t wait- depression is an illness that can, and should be treated.

Thoughts about death or suicide are common in depression, and it’s important to take such thoughts seriously. If you feel like giving up or as if you might hurt yourself, get help immediately: call your doctor, go to the emergency room or call 911.

This tool is adapted with permission from similar content found on www.depressionhurts.ca.


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