December 20, 2014
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Exelon Patch

(rivastigmine patch)

DIN (Drug Identification Number)

02302845 EXELON TRANSDERMAL PATCH 5 (4.6MG/24 HOUR)
02302853 EXELON TRANSDERMAL PATCH 10 (9.5MG/24 HOUR)

How does Exelon Patch work? What will it do for me?

Rivastigmine belongs to a family of medications known as cholinesterase inhibitors. It is used to treat symptoms of mild to moderate Alzheimer's disease.

Alzheimer's disease is caused by the constant degeneration of certain nerve cells in the brain that make a chemical called acetylcholine. This chemical is thought to be important for the processes of learning and memory. Rivastigmine prevents the breakdown of acetylcholine, thereby increasing its levels in the brain. Rivastigmine may improve cognitive function (memory, orientation, and language) and general ability to perform activities of daily living. Rivastigmine patch may take several weeks to begin working, and individual response varies.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

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How should I use Exelon Patch?

The usual recommended starting dose is to apply one patch of the lowest dose (4.6 mg released every 24 hours) once a day. Your doctor may increase the dose (to a patch that releases 9.5 mg every 24 hours) after 4 weeks of treatment. The highest dose recommended is 9.5 mg every 24 hours.

Apply the patch to clean, dry, non-irritated skin on a flat body surface such as the chest, upper back, lower back, or upper arm. Make sure there is no hair, powder, oil, moisturizer, or lotion at the application site. The patch should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure the contact is complete, especially around the edges.

Each patch may be worn continuously for 24 hours, after which time the old patch should be removed and a new patch should be applied. Apply the new patch on a different skin site after removal of the previous one and do not apply a new patch to the same spot for at least 2 weeks. Consult the package insert, your doctor, or your pharmacist for specific instructions on how to use and properly dispose of the medication.

Only one patch may be worn at a time. After 24 hours, there is still medication remaining in the patch. If two patches are worn at the same time, there is a high likelihood of severe side effects occurring, including heart attack and death. Do not use the patch if it is cut, damaged, or altered in any way.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you forget to apply a new rivastigmine patch, remove the old one and apply a new patch as soon as possible. Continue with your regular dosing schedule for your next patch. Do not apply two patches to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss several days of applying the rivastigmine patch, consult your doctor first before you begin to apply the next patch.

Store this medication at room temperature, in the original packaging. Protect it from light and heat, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Exelon Patch come in?

Exelon Patch 5
Each patch of 5 cm² contains 9 mg rivastigmine base, with in vivo release rate of 4.6 mg/24 hours. The outside of the backing layer is beige and labelled with "PrEXELON* PATCH 5 (rivastigmine) 4.6 mg/24 h" and "AMCX". Nonmedicinal ingredients: acrylic copolymer, poly (butylmethacrylate, methyl-methacrylate), silicone adhesive applied to a flexible polymer backing film, silicone oil, and vitamin E.

Exelon Patch 10
Each patch of 10 cm² contains 18 mg rivastigmine base, with in vivo release rate of 9.5 mg/24 hours. The outside of the backing layer is beige and labelled with "PrEXELON* PATCH 10 (rivastigmine) 9.5 mg/24 h" and "BHDI". Nonmedicinal ingredients: acrylic copolymer, poly (butylmethacrylate, methyl-methacrylate), silicone adhesive applied to a flexible polymer backing film, silicone oil, and vitamin E.

Who should NOT take Exelon Patch?

Do not use rivastigmine patch if you:

  • are allergic to rivastigmine or any of ingredients of the medication
  • are allergic to medications that are similar to rivastigmine
  • have severely reduced liver function

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