August 21, 2014
ABCDEFGHIJKLMNOPQRSTUVWXYZ

Drug Factsheets

 Health Home >> Medications 

Activelle

(norethindrone acetate - estradiol)

DIN (Drug Identification Number)

02249405 ACTIVELLE 0.5/1 MG TABLET

How does Activelle work? What will it do for me?

This is a combination medication that contains estradiol and norethindrone acetate. Estradiol belongs to the class of medications called estrogens, while norethindrone acetate belongs to the class of medications known as progestins.

This medication is used as an oral hormone replacement therapy to relieve menopausal symptoms and vaginal symptoms associated with menopause.

Estrogens and progestins are female hormones. They are produced by the body and are needed for normal female sexual development and for regulating the menstrual cycle during the childbearing years. During and after menopause, the ovaries start to produce less of these hormones. A deficiency of estrogen can result in symptoms associated with menopause such as hot flashes, unusual sweating, chills, dryness of the vagina, and sleep disturbances.

This medication is designed for women who have not had a hysterectomy (removal of the uterus or womb). These women require progestin while taking estrogen to prevent complications associated with taking estrogen alone, such as the overgrowth of the uterine lining (endometrial hyperplasia).

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Activelle?

The recommended dose of norethindrone acetate - estradiol is one tablet daily at approximately the same time each day, with or without food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication be taken prescribed by your doctor. If you miss a dose, take it as soon as you remember and continue with your regular schedule. If it is within 12 hours of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Activelle come in?

Each white, round, biconvex, film-coated tablet engraved with "NOVO 288" on one side and "APIS" on the other side contains estradiol 1 mg (as the hemihydrate) and norethindrone acetate 0.5 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, copovidone, talc, magnesium stearate, hypromellose, and triacetin.

Who should NOT take Activelle?

Do not take this medication if you:

  • are allergic to estradiol, norethindrone acetate, or any ingredients of this medication
  • are breast-feeding
  • are or may be pregnant
  • have active liver disease
  • have classical migraines
  • have endometrial hyperplasia (thickening of the inner lining of the uterus)
  • have had a hysterectomy (removal of the uterus)
  • have known or suspected estrogen-dependent or progestin-dependent tumours such as breast cancer or endometrial cancer, or a history of any of these cancers
  • have or have had a stroke or heart attack or coronary heart disease
  • have or have had active blood clotting disorders (e.g., thrombophlebitis, deep vein thrombosis, or pulmonary embolism)
  • have partial or complete loss of vision from blood vessel disease of the eyes
  • have porphyria
  • have unusual vaginal bleeding that has not been checked by a doctor

Continued... 1 | 2 | Next


Did you find what you were looking for on our website? Please let us know.

Ad

The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical condition(s) and treatment(s). This site is not a substitute for medical advice.

© 1996 - 2014 MediResource Inc. - MediResource reaches millions of Canadians each year.