November 23, 2014
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NovoMix 30

(insulin aspart mix)

DIN (Drug Identification Number)

02265435 NOVOMIX 30 (PENFILL CARTRIDGE) SUSPENSION FOR INJ

How does NovoMix 30 work? What will it do for me?

Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. Insulin aspart mix contains insulin aspart and insulin aspart protamine crystals. Insulin aspart is a rapid-acting insulin. It takes 10 to 15 minutes to begin working after the injection, has its maximum effect between 60 and 180 minutes, and stops working after 3 to 5 hours.

Insulin aspart protamine crystals are absorbed more slowly than insulin aspart, lowering the blood glucose levels over a prolonged period of time. When mixed together they start working within 10 to 20 minutes following injection, reach a maximum effect between 1 to 4 hours after injection and lasts up to 24 hours.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it. Never share your pen with anyone else as you may transmit serious diseases.

How should I use NovoMix 30?

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin) exactly as instructed by your doctor or diabetes educator. Do not inject insulin aspart mix into the vein and do not use insulin aspart mix in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. Insulin aspart mix is injected under the skin not more than 5 to 10 minutes before the start of a meal. There are many variations of insulin dosing.

Insulin aspart mix is a white suspension available in cartridges. It is used in a special device that looks like a pen. The mixture should be uniformly white and cloudy. Do not use the insulin if you notice anything unusual in the appearance of the solution, such as a frosted appearance.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is very important that you use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Keep unopened cartridges of insulin in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Insulin must not be exposed to extremely hot temperatures or to sunlight. Keep insulin out of reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does NovoMix 30 come in?

Each mL of sterile, uniform, white suspension contains insulin aspart (B28 asp regular human insulin analogue; 30% insulin aspart and 70% insulin aspart protamine crystals) 100 units. Nonmedicinal ingredients: glycerol, phenol, metacresol, zinc, disodium hydrogen phosphate dihydrate, sodium chloride, protamine sulfate, sodium hydroxide, hydrochloric acid, and water for injection.

Who should NOT take NovoMix 30?

Insulin aspart mix should not be used by anyone who:

  • is allergic to or has a suspected allergy to insulin or to any ingredients of the medication
  • has diabetic coma
  • has low blood glucose (hypoglycemia)

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