September 2, 2014
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Rasilez HCT

(aliskiren - hydrochlorothiazide)

DIN (Drug Identification Number)

02332728 RASILEZ HCT 150 MG/12.5MG TABLET
02332736 RASILEZ HCT 150 MG/25MG TABLET
02332744 RASILEZ HCT 300MG/12.5MG TABLET
02332752 RASILEZ HCT 300MG/25MG TABLET

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How does Rasilez HCT work? What will it do for me?

This is a combination medication that contains aliskiren and hydrochlorothiazide. It is used to treat high blood pressure for people who have been taking at least one of these medications on its own.

Aliskiren belongs to a group of medications called direct rennin inhibitors, which lower blood pressure by blocking the actions of renin (a chemical that causes blood vessels to tighten). Hydrochlorothiazide belongs to a group of medications called diuretics, which lower blood pressure by helping the kidneys get rid of excess salt and water.

This medication starts to work within a week, with full effect seen within 4 weeks.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Rasilez HCT?

The usual recommended dose is one tablet daily, covering a dose range of 150 mg to 300 mg of aliskiren with 12.5 mg to 25 mg of hydrochlorothiazide. The dose of aliskiren - hydrochlorothiazide is different for each person and depends on the dose(s) of aliskiren and hydrochlorothiazide you were taking before starting this combination medication.

Take this medication with or without food, but take it the same way each day and at the same time. Swallow the tablets whole with a small amount of water. Do not chew or crush the tablets.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Rasilez HCT come in?

150 mg/12.5 mg
Each white, biconvex, ovaloid film-coated tablet, imprinted with "LCI" on one side and "NVR" on the other contains aliskiren 150 mg (as aliskiren fumarate) and hydrochlorothiazide 12.5 mg. Nonmedicinal ingredients: cellulose, microcrystalline, crospovidone, lactose monohydrate, wheat starch, povidone, magnesium stearate, silica colloidal anhydrous, talc, hypromellose, macrogol, and titanium dioxide (E 171).

150 mg/25 mg
Each pale yellow, biconvex, ovaloid film-coated tablet, imprinted with "CLL" on one side and "NVR" on the other side contains aliskiren 150 mg (as aliskiren fumarate) and hydrochlorothiazide 25 mg. Nonmedicinal ingredients: cellulose, microcrystalline, crospovidone, lactose monohydrate, wheat starch, povidone, magnesium stearate, silica colloidal anhydrous, talc, hypromellose, macrogol, iron oxide red (E 172) iron oxide yellow (E172), and titanium dioxide (E 171).

300 mg/12.5 mg
Each violet white, biconvex, ovaloid tablet, imprinted with "CVI" on one side and "NVR" on the other side contains aliskiren 300 mg (as aliskiren fumarate) and hydrochlorothiazide 12.5 mg. Nonmedicinal ingredients: cellulose, microcrystalline, crospovidone, lactose monohydrate, wheat starch, povidone, magnesium stearate, silica colloidal anhydrous, talc, hypromellose, macrogol, iron oxide black (E 172), iron oxide red (E 172), and titanium dioxide (E 171).

300 mg/25 mg
Each light yellow, biconvex , ovaloid tablet imprinted with "CVV" on one side and "NVR" on the other side contains aliskiren 300 mg (as aliskiren fumarate) and hydrochlorothiazide 25 mg. Nonmedicinal ingredients: cellulose, microcrystalline, crospovidone, lactose monohydrate, wheat starch, povidone, magnesium stearate, silica colloidal anhydrous, talc, hypromellose, macrogol, iron oxide red (E 172), iron oxide yellow (E172), and titanium dioxide (E 171).

Who should NOT take Rasilez HCT?

Do not take this medication if you:

  • are allergic to aliskiren, hydrochlorothiazide, sulfonamide medications (e.g., sulfamethoxazole), or any ingredients of this medication
  • are pregnant
  • have anuria (difficulty making urine)
  • have diabetes or reduced kidney function and are also taking high blood pressure medications belonging to the ACE inhibitors family (e.g., lisinopril, ramipril) or the ARB family (e.g., candesartan, losartan)
  • have experienced swelling (e.g. around the eyes or lips, hands or feet) while taking aliskiren or medications belonging to the ACE inhibitors family (e.g. lisinopril, ramipril) or ARB family (e.g. candesartan, losartan)
  • have gout symptoms and high levels of uric acid in the blood
  • have hereditary angioedema or idiopathic angioedema (angioedema of unknown cause)
  • have low sodium or potassium levels in your blood, or have high calcium levels in your blood despite being treated

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