October 22, 2014
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Drug Factsheets

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Mazepine

(carbamazepine)

DIN (Drug Identification Number)

00504742 Mazepine 200 mg Tablet

How does Mazepine work? What will it do for me?

Carbamazepine is used to manage certain types of seizures, alone or in combination with other medications. It is also used to treat the nerve pain of trigeminal neuralgia and to treat acute mania and prevention of bipolar (manic-depressive) disorders.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Mazepine?

Recommended doses of carbamazepine vary greatly, depending on the condition being treated and the age and circumstances of the person being treated.

Seizure disorder: The starting dose for adults and children over 12 years of age is 100 mg to 200 mg once or twice daily. Depending on the effectiveness of the medication, the doctor may increase the dose gradually up to 1,600 mg daily in divided doses. Most people achieve the best response at daily doses between 800 mg and 1,200 mg.

The starting dose for children between 6 and 12 years of age is 100 mg daily in divided doses and increased by 100 mg daily until the best response is achieved. The daily maximum dose for children is 1,000 mg daily in divided doses.

If carbamazepine is being added to medications that are already being taken for seizures, the starting doses may be lower.

Trigeminal neuralgia pain: The starting dose of carbamazepine for treating the pain of trigeminal neuralgia is 100 mg taken twice daily. The dose is increased to a maximum of 1,200 mg daily, depending on the effectiveness of the medication.

Mania and bipolar disorders: The usual starting dose for the treatment of mania and bipolar disorders is 200 mg to 400 mg daily, taken in divided doses. The daily dose is then increased as instructed by the doctor to a maximum of 1,600 mg daily. If other medications, such as lithium, are being taken, the starting dose will be lower.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Carbamazepine should be taken with meals whenever possible.

The controlled release tablets should be swallowed whole with some liquid during or after a meal. They should not be crushed or chewed.

When taking carbamazepine suspension, shake the medication bottle well before measuring the dose of medication. An oral syringe should be used to measure each dose of the liquid, as it provides a more accurate measurement than household teaspoons.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store all forms of this medication at room temperature, away from humidity, and out of reach of children. The chewable tablets and liquid should be protected from light.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Mazepine come in?

Each white, round, compressed tablet, scored on one side and embossed "ICN M11" on the other side, contains carbamazepine 200 mg. Nonmedicinal ingredients: lactose, povidone, eudragit, starch, microcrystalline cellulose, magnesium stearate, and sodium carboxymethyl starch.


Who should NOT take Mazepine?

Do not take carbamazepine if you:

  • are allergic to carbamazepine or any ingredients of the medication
  • are allergic to tricyclic compounds such as amitriptyline, trimipramine, or imipramine
  • have a history of acute intermittent porphyria
  • have a history of bone marrow depression
  • have a serious blood disorder
  • have severe heart disease (heart block)
  • have liver disease
  • have taken an MAO inhibitor (e.g., phenelzine, tranylcypromine) within the past 14 days or will take one within the next 14 days (If you have taken an MAO inhibitor recently but more than 14 days ago, your dosage of carbamazepine should be low initially, and increased very gradually.)
  • are taking the antifungal medication itraconazole or voriconazole

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