September 30, 2014
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Drug Factsheets

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Renvela

(sevelamer carbonate)

DIN (Drug Identification Number)

02354586 RENVELA 800 MG TABLET

How does Renvela work? What will it do for me?

Sevelamer carbonate belongs to the class of medications called phosphate binders. Phosphate is made up mostly of the mineral phosphorus, which is an important component of normal bone structure, cell metabolism, and cell function.

In the body, the kidneys help keep the amount of phosphorus in the blood at a relatively constant level. For people with kidney problems, as their kidney function decreases, less phosphorus is removed from the body, potentially leading to a condition known as hyperphosphatemia (high phosphate levels in the blood). High levels of phosphorus in the blood can lead to problems with the strength and structure of bones. This condition is known as renal osteodystrophy.

When taken with meals, sevelamer carbonate prevents the absorption of phosphates from food by binding to the phosphate. It is used specifically to control high levels of phosphate (and therefore phosphorus) in the blood of people with severe kidney disease, known as end stage renal disease (ESRD), who are receiving dialysis (hemodialysis or peritoneal dialysis).

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Renvela?

The dose of sevelamer carbonate depends on the amount of phosphorus that is present in the blood. The starting dose can range from 2.4 g to 4.8 g each day. Total daily doses of sevelamer carbonate is usually divided according to meal portions where higher doses of sevelamer carbonate are given with larger meals.

Your doctor may gradually increase the total daily dose of sevelamer carbonate according to the phosphorus level in your blood. Tablets should be taken immediately before meals or with meals. Do not bite, chew, or break apart the tablet before swallowing.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Renvela come in?

Each white, oval, film-coated tablet, imprinted with "RENVELA 800" contains 800 mg of sevelamer carbonate on an anhydrous basis. Nonmedicinal ingredients: microcrystalline cellulose, sodium chloride, and zinc stearate; coating: hypromellose and diacetylated monoglycerides; printing ink: hypromellose, iron oxide black ink, propylene glycol, and isopropyl alcohol.

Who should NOT take Renvela?

Do not take sevelamer carbonate if you:

  • are allergic to sevelamer carbonate or to any of the ingredients of the medication
  • have a bowel obstruction
  • have low levels of phosphorus in your blood

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