April 24, 2014
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Drug Factsheets

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Zyclara

(imiquimod 3.75% cream (for actinic keratosis))

DIN (Drug Identification Number)

02340445 IMIQUIMOD 3.75% CREAM

How does Zyclara work? What will it do for me?

Imiquimod cream belongs to a group of medications called immune response modifiers. It works by stimulating the body's defenses to fight certain types of skin conditions. Imiquimod cream is used to treat actinic keratosis (AK) on the face or balding scalp in adults. AK is a skin condition that could turn into skin cancer (symptoms include rough, red, scaly patches or lesions, or crusts) that is caused by chronic sun exposure.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Zyclara?

Before applying the cream, wash your hands with soap and water, gently wash the treatment area with mild soap and water, and allow the skin to dry thoroughly. Apply imiquimod cream to the affected skin area once daily just before going to bed. Do not apply to areas larger than either the face or the balding scalp. Apply a thin layer of this medication onto the clean, dry AK lesion and rub gently into the skin until the cream is absorbed. Avoid contact with eyes, lips, and nostrils. If the cream gets in your eyes, rinse them with large amounts of water. Wash your hands after using the medication. Do not apply an occlusive dressing (one made of airtight material) over this medication.

Leave the medication on the skin area for approximately 8 hours, and then remove it by washing the treated area with mild soap and water. Continue to use this medication for a total of 2 treatment cycles of 2 weeks, separated by a 2-week period with no treatment, or as directed by your doctor. A rest period from medication for several days may be taken depending on your discomfort and the severity of skin reactions, as directed by your doctor. Each treatment cycle should not last longer than 2 weeks even if a rest period is taken.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

This medication is for external use only. Do not take it by mouth.

You may apply up to 2 packets or medication or 2 full actuations of the pump to the treatment area. If you are using the packets, use a new packet for each application. Throw away the remainder of an opened packet each time.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and apply the cream at bedtime the next night. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, prevent it from freezing, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Zyclara come in?

2.5%
Each gram of off-white to faintly yellow cream contains imiquimod 25 mg (2.5%). Nonmedicinal ingredients: isostearic acid, cetyl alcohol, stearyl alcohol, white petrolatum, polysorbate 60, sorbitan monostearate, glycerin, xanthan gum, purified water, benzyl alcohol, methylparaben, and propylparaben.

3.75%
Each gram of off-white to faintly yellow cream contains imiquimod 37.5 mg (3.75%). Nonmedicinal ingredients: isostearic acid, cetyl alcohol, stearyl alcohol, white petrolatum, polysorbate 60, sorbitan monostearate, glycerin, xanthan gum, purified water, benzyl alcohol, methylparaben, and propylparaben.

Who should NOT take Zyclara?

Do not use this medication if you are allergic to imiquimod or any ingredients of the medication.

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