September 30, 2014
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Drug Factsheets

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Apo-Terbinafine

(terbinafine)

DIN (Drug Identification Number)

02239893 APO-TERBINAFINE 250MG TABLET

What side effects are possible with Apo-Terbinafine?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

    Tablets:

  • change of taste or loss of taste
  • diarrhea
  • feeling of fullness in the stomach
  • heartburn
  • joint or muscle aches
  • nausea and vomiting
  • stomach pain (mild)
  • Cream, spray:

  • burning
  • dryness
  • itching
  • other signs of skin irritation not present before use of this medication
  • peeling
  • rash
  • redness
  • stinging
  • tingling

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

    Tablets:

  • aching joints and muscles
  • changes in sense of taste lasting for several days
  • continuing headache
  • difficulty swallowing
  • pale skin
  • skin rash or itching
  • stomach pain or vomiting

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a serious allergic reaction (such as hives, difficulty breathing, or swelling of the face or throat)
  • symptoms of a serious skin rash (such as redness, blistering, peeling, or loosening of skin)
  • symptoms of blood disorders (such as sore throat, fever, chills, mouth sores, or unusual bleeding or bruising)
  • symptoms of liver problems (such as unusual fatigue, yellow eyes or skin, abdominal pain, dark urine, pale stools, itching, or loss of appetite)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Apo-Terbinafine?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

External use only: Terbinafine cream and spray are for external use only. Avoid contact with the eyes. Do not use the spray on the face. In case of accidental contact with the eyes, rinse eyes thoroughly with running water and consult a doctor if any symptoms persist. In case of inhalation, contact a doctor if any symptoms develop and persist.

Liver problems: Terbinafine tablets are not recommended for people with chronic or active liver disease. Your doctor may order liver function tests while you are taking terbinafine tablets. During treatment with terbinafine, report to your doctor any signs or symptoms of liver problems including unusual fatigue, loss of appetite, yellowing of skin or eyes, abdominal pain, nausea and vomiting, dark urine, pale stools, or itching.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking terbinafine, it may affect your baby. Women taking terbinafine tablets should not breast-feed. If you are using the cream or spray, talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with Apo-Terbinafine?

There may be an interaction between terbinafine and any of the following:

  • amiodarone
  • antihypertensives (medications that lower blood pressure; e.g., metoprolol, propranolol)
  • atomoxetine
  • birth control pills
  • carbamazepine
  • cimetidine
  • codeine
  • cyclosporine
  • dextromethorphan
  • flecainide
  • fluconazole
  • haloperidol
  • itraconazole
  • ketoconazole
  • MAO inhibitors type B (e.g., selegiline)
  • mercaptopurine
  • phenobarbital
  • phenothiazines (e.g., chlorpromazine, thioridazine)
  • phenytoin
  • primidone
  • propafenone
  • rifabutin
  • rifampin
  • SSRIs (e.g., fluoxetine, paroxetine)
  • tamoxifen
  • tetrabenazine
  • theophylline
  • triazolam
  • tricyclic antidepressants (e.g., amitriptyline, desipramine)
  • tolbutamide
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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