November 1, 2014
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Drug Factsheets

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Twynsta

(amlodipine - telmisartan)

DIN (Drug Identification Number)

02371022 TWYNSTA 5MG / 40MG TABLET
02371030 TWYNSTA 10MG / 40MG TABLET
02371049 TWYNSTA 5MG / 80MG TABLET
02371057 TWYNSTA 10MG / 80MG TABLET

How does Twynsta work? What will it do for me?

This is a combination medication that contains amlodipine and telmisartan. Amlodipine belongs to the group of medications called calcium channel blockers and telmisartan belongs to the group of medications called angiotensin II receptor blockers.

Amlodipine - telmisartan is used to treat mild to moderate high blood pressure for people who have been taking amlodipine and telmisartan as separate tablets. It works by relaxing blood vessel walls.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Twynsta?

The usual dose of this medication depends on the dose of amlodipine and telmisartan taken separately before starting this medication. The dose is taken once daily, the same time of day, preferably in the morning.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Amlodipine - telmisartan may be taken with or without food.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature in the original package, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Twynsta come in?

40 mg/5 mg
Each oval-shaped, biconvex, uncoated, bilayer tablet with one layer white to off-white and the other layer blue, marked with the company logo and "A1" contains 40 mg telmisartan and 5 mg amlodipine. Nonmedicinal ingredients: colloidal anhydrous silica, FD&C Blue No. 1 Aluminium Lake (E 133), ferric oxide black (E172), ferric oxide yellow (E172), magnesium stearate, maize starch, meglumine, microcrystalline cellulose, povidone K25, pregelatinized starch, sodium hydroxide, and sorbitol (E420).

40 mg/10 mg
Each oval-shaped, biconvex, uncoated, bilayer tablet with one layer white to off-white and the other layer blue, marked with the company logo and "A2" contains 40 mg telmisartan and 10 mg amlodipine. Nonmedicinal ingredients: colloidal anhydrous silica, FD&C Blue No. 1 Aluminium Lake (E 133), ferric oxide black (E172), ferric oxide yellow (E172), magnesium stearate, maize starch, meglumine, microcrystalline cellulose, povidone K25, pregelatinized starch, sodium hydroxide, and sorbitol (E420).

80 mg/5 mg
Each oval-shaped, biconvex, uncoated, bilayer tablet with one layer white to off-white and the other layer blue, marked with the company logo and "A3" contains 80 mg telmisartan and 5 mg amlodipine. Nonmedicinal ingredients: colloidal anhydrous silica, FD&C Blue No. 1 Aluminium Lake (E 133), ferric oxide black (E172), ferric oxide yellow (E172), magnesium stearate, maize starch, meglumine, microcrystalline cellulose, povidone K25, pregelatinized starch, sodium hydroxide, and sorbitol (E420).

80 mg/10 mg
Each oval-shaped, biconvex, uncoated, bilayer tablet with one layer white to off-white and the other layer blue, marked with the company logo and "A4" contains 80 mg telmisartan and 10 mg amlodipine. Nonmedicinal ingredients: colloidal anhydrous silica, FD&C Blue No. 1 Aluminium Lake (E 133), ferric oxide black (E172), ferric oxide yellow (E172), magnesium stearate, maize starch, meglumine, microcrystalline cellulose, povidone K25, pregelatinized starch, sodium hydroxide, and sorbitol (E420).

Who should NOT take Twynsta?

Do not take this medication if you:

  • are allergic to amlodipine, telmisartan, or any ingredients of the medication
  • are allergic to similar medications (e.g., calcium channel blockers, ARBs)
  • are breast-feeding
  • are pregnant
  • have a rare hereditary condition of fructose intolerance (this medication contains sorbitol)
  • have biliary obstruction (problems with the draining of bile from the liver and gall bladder)
  • have severe liver problems
  • have low heart output because of a serious heart problem

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