October 25, 2014
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Drug Factsheets

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Estragyn Vaginal Cream

(estrone)

DIN (Drug Identification Number)

00727369 ESTRAGYN VAGINAL CREAM 0.1%

How does Estragyn Vaginal Cream work? What will it do for me?

Estrone vaginal cream belongs to the class of medications known as estrogen replacement therapy. Estrone vaginal cream is used to manage vaginal menopausal symptoms such as itching, burning, dryness in or around the vagina, and painful sexual intercourse.

Estrogen is a hormone that is produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and symptoms of menopause can occur. Estrone vaginal cream works by providing locally acting estrogen.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Estragyn Vaginal Cream?

The dose of this medication is individualized to the person using the cream. The lowest dose that will treat the symptoms should be used.

The recommended adult dose of estrone vaginal cream ranges from 2 g to 4 g of cream daily. The cream is inserted into the vagina using the applicator provided. The cream is usually used on a regular cycle, with 3 weeks of use followed by 1 week off. Sometimes the cream is used continuously. Follow your dcotor's instructions. Treatment should be stopped as soon as possible because estrone vaginal cream is intended only for short-term use.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

To use the applicator, remove the cap of the tube of cream and screw the nozzle end of the applicator onto the tube. Squeeze the cream until it reaches the mark that indicates the dose prescribed by your doctor. Unscrew the applicator from the tube, place it into the opening of the vagina, and gently press the plunger to release the medication. Clean the applicator by pulling the plunger out from the barrel and washing it with mild soap and warm water.

Women who also take oral estrogen tablet may need to have the dose of their tablets adjusted when they start using the cream. Women who have not had their uterus removed should also take a progestin (such as medroxyprogesterone acetate). Talk with your doctor or pharmacist about which dosing schedule would work best for you if you are taking a progestin.

It is important that this medication be taken exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Estragyn Vaginal Cream come in?

Each gram of cream contains 0.1% w/w estrone. Nonmedicinal ingredients: arlacel 165, isopropyl myristate, methyl paraben, mineral oil, Peg 40 stearate, propyl paraben, sorbitan monostearate, stearic acid, and water.

Who should NOT take Estragyn Vaginal Cream?

Do not use estrone vaginal cream if you:

  • are allergic to estrone or any ingredients of the medication
  • are or may be pregnant
  • are breast-feeding
  • have a history of known or suspected estrogen-dependent tumours such as breast or uterine cancer
  • have abnormal liver test results caused by liver disease or liver problems
  • have endometrial hyperplasia (overgrowth of the lining of the uterus)
  • have or have had a history of blood clots (e.g., in the legs or lungs), heart attack, stroke, or heart disease
  • have any vision problems or other vision problems due to ophthalmic vascular disease (disease involving blood vessels of the eye)
  • have undiagnosed abnormal vaginal bleeding
  • have a history of migraine headaches with aura (classical migraine)

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