December 22, 2014
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Drug Factsheets

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Clozaril

(clozapine)

DIN (Drug Identification Number)

00894745 CLOZARIL 100MG TABLET
00894737 CLOZARIL 25MG TABLET

How does Clozaril work? What will it do for me?

Clozapine belongs to a family of medications called antipsychotics. It is used to treat schizophrenia when other medications are not effective. Schizophrenia is related to imbalances in certain brain chemicals such as dopamine. This medication helps to balance these chemicals.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use Clozaril?

The recommended dose varies widely based on need but is usually started at 12.5 mg taken once or twice daily and adjusted gradually upwards according to the doctor's instructions.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Do not stop taking this medication without talking to your doctor. If it becomes necessary to stop this medication, the dose should be reduced gradually to prevent withdrawal effects. Stopping clozapine too quickly can cause a return of the symptoms you originally started taking the medication for as well as headache, nausea, vomiting, and diarrhea.

It is important to take this medication exactly as prescribed. If you miss a dose of this medication and remember within 2 hours, take it as soon as possible. However, if it has been more than 2 hours, skip the missed dose and go back to your regular dosing schedule. If you miss 2 or more days of clozapine doses, talk to your doctor before restarting the medication. You may need to start taking the medication at a lower dose than you were taking previously.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Clozaril come in?

25 mg
Each round, pale yellow, uncoated, easy to break, scored tablet, embossed "CLOZARIL" on one side and "25 mg" on the other, contains clozapine 25 mg. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and talc.

100 mg
Each round, pale yellow, uncoated, easy to break, scored tablet, embossed "CLOZARIL" on one side and "100 mg" on the other, contains clozapine 100 mg. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and talc.

Who should NOT take Clozaril?

Do not take this medication if you:

  • are allergic to clozapine or any ingredients of this medication
  • are unable to undergo regular blood tests
  • have active liver disease associated with nausea, loss of appetite, or jaundice (yellowing of skin)
  • have certain blood disorders (e.g., platelet disorders, low white blood cells)
  • have obstruction of the bowels
  • have severe heart disease (e.g., myocarditis)
  • have severe kidney disease
  • have uncontrolled epilepsy
  • have problems with drug or alcohol abuse

Do not give this medication to people who are in a severely sedated or comatose state.

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