October 25, 2014
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Drug Factsheets

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Depo-Provera

(medroxyprogesterone acetate injection)

DIN (Drug Identification Number)

00585092 DEPO-PROVERA STERILE AQUEOUS SUSPENSION 150MG/ML
00030848 DEPO-PROVERA STERILE AQUEOUS SUSPENSION 50MG/ML

How does Depo-Provera work? What will it do for me?

Medroxyprogesterone acetate belongs to the class of medication known as progestogens. It is used to prevent pregnancy. It works by preventing a woman's egg from completely developing. It also thickens the mucus around the cervix, making it harder for sperm to reach the egg. Medroxyprogesterone acetate is also used to treat endometriosis.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

How should I use Depo-Provera?

Birth control: The recommended dose is 150 mg injected into a muscle by a health care professional every 3 months, usually started within the first 5 days after the onset of a normal menstrual period. Intervals between injections must not be more than 13 weeks. If an injection is not received within 13 weeks, a pregnancy test should be done before any further treatment with medroxyprogesterone.

If the injection is given within the first 5 days after the onset of a normal menstrual period, it is effective from the day of injection. However, if it is given later during the menstrual cycle, it may not be effective for the first 3 to 4 weeks after the injection. A non-hormonal "back up" method of birth control, such as latex condoms with spermicidal foam or jelly, should be used during this time.

Endometriosis: The usual dose is 50 mg injected into a muscle once a week, or 100 mg injected into a muscle every second week for at least 6 months.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is very important that this medication be used exactly as prescribed by the doctor. This preparation is not to be used intravenously (injected into a vein). If you miss an appointment to receive medroxyprogesterone acetate injection, contact your doctor as soon as possible to reschedule your appointment.

Store this medication at room temperature, protect it from freezing and light, and keep it out of the reach of children. It should be shaken well just before using.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Depo-Provera come in?

50 mg/mL
Each mL contains medroxyprogesterone acetate 50 mg. Nonmedicinal ingredients: hydrochloric acid, methylparaben, polyethylene glycol, polysorbate, propylparaben, sodium chloride, sodium hydroxide, and water for injection.

150 mg/mL
Each mL contains: medroxyprogesterone acetate 150 mg. Nonmedicinal ingredients: hydrochloric acid, methylparaben, polyethylene glycol, polysorbate, propylparaben, sodium chloride, sodium hydroxide, and water for injection.

Who should NOT take Depo-Provera?

Medroxyprogesterone should not be used by a woman who:

  • is allergic to medroxyprogesterone or to any of the ingredients of the medication
  • is or may be pregnant
  • has a history of clotting disorders, or who are at increased risk for clotting disorders
  • has a history of heart attack or heart disease
  • has a history of migraines with auras
  • has a history of stroke
  • has liver disease
  • has or may have a cancer that is dependent on progestin
  • has undiagnosed vaginal or urinary tract bleeding
  • has undiagnosed or confirmed breast problems (e.g., cancer)
  • has vision problems because of vascular disease

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