April 20, 2014
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Drug Factsheets

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Dermovate

(clobetasol 17 - propionate)

DIN (Drug Identification Number)

02213265 DERMOVATE 0.05% CREAM
02213273 DERMOVATE 0.05% OINTMENT
02213281 DERMOVATE SCALP 0.05% LOTION

What side effects are possible with Dermovate?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burning, dryness, irritation, itching, or redness of skin (usually mild and temporary)
  • eye pain (if certain products have been used near the eye)
  • headache
  • increased redness or scaling of skin sores (usually mild and temporary)
  • skin colour changes
  • skin infection
  • skin rash (usually mild and temporary)
  • softening and tearing of the skin
  • thinning of skin with easy bruising

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • acne or oily skin
  • burning and itching of skin
  • lack of healing of skin condition
  • numbness in fingers
  • painful, red, or itchy pus-containing blisters in hair follicles
  • unusual increase in hair growth, especially on the face
  • visible lines or small blood vessels under the skin
  • unusual loss of hair, especially on the scalp

The following side effects may occur if this medication is used improperly or for a long time:

  • backache
  • blurring or loss of vision (occurs gradually if certain products have been used near the eye)
  • burning and itching of skin with pinhead-sized red blisters
  • filling or rounding out of the face
  • increased blood pressure
  • irregular heartbeat
  • irregular menstrual periods
  • irritability
  • irritation of skin around mouth
  • loss of appetite
  • depression
  • muscle cramps, pain, or weakness
  • nausea
  • rapid weight gain or loss
  • reddish-purple lines (stretch marks) on arms, face, legs, trunk, or groin
  • skin colour changes
  • stomach bloating, burning, cramping, or pain
  • swelling of feet or lower legs
  • unusual bruising
  • unusual decrease in sexual desire or ability (in men)
  • unusual tiredness or weakness
  • vomiting
  • weakness of the arms, legs, or trunk (severe)
  • worsening of infections

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using this medication.





Are there any other precautions or warnings for Dermovate?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform all of your doctors that you are using topical (skin-applied) corticosteroids.

Absorption: When clobetasol 17 - propionate is used over extensive areas for prolonged periods and under dressings that don't breathe, it is possible that enough medication will absorb into the bloodstream to cause unwanted side effects. Therefore, it is advisable to use this medication for brief periods only and to stop using it as soon as the problem clears. Talk to your health care provider about how long you should use this medication.

Diabetes: When clobetasol 17-propionate is used over large areas of the body for prolonged periods or under dressings that don't breathe it is possible that enough medication will absorb into the bloodstream to affect blood sugar levels. If you have diabetes, your doctor should closely monitor your condition while you are using clobetasol 17-propionate, as it may affect blood sugar control (either increase or decrease blood sugar levels).

Eyes: Use this medication with care on lesions close to the eye. Getting the medication in the eye can increase the risk of increased eye pressure, glaucoma, or cataracts.

Infection: Contact your doctor if any infection is noticed around the area of application.

Thinning of skin: Prolonged use of topical corticosteroid products may produce thinning of the skin and tissues under it. If you notice this effect, call your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using this medication, contact your doctor immediately.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are using clobetasol 17-propionate, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Children are more likely to experience absorption of this medication into the bloodstream, resulting in unwanted effects. The safety and effectiveness of using this medication have not been established for children. Its use by children is not recommended.

What other drugs could interact with Dermovate?

There may be an interaction between clobetasol 17 - propionate and any of the following:

  • aldesleukin
  • other topical medications that contain corticosteroids or that have irritating effects to the skin

If you are using any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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