October 1, 2014
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Drug Factsheets

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ISDN

(isosorbide dinitrate)

DIN (Drug Identification Number)

00441686 ISDN 10MG TABLET
00441694 ISDN 30MG TABLET
00670944 ISDN 5MG SUBLINGUAL TABLET

What side effects are possible with ISDN?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fast pulse
  • flushing of face and neck
  • headache
  • nausea or vomiting
  • restlessness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision
  • dryness of mouth
  • fainting
  • headache (severe or prolonged)
  • skin rash

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fast pulse
  • flushing of face and neck
  • headache
  • nausea or vomiting
  • restlessness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision
  • dryness of mouth
  • fainting
  • headache (severe or prolonged)
  • skin rash

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for ISDN?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Medical conditions: If you have low blood pressure, glaucoma, or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Tolerance: The body can get used to the effects of isosorbide dinitrate (develop a tolerance), especially if the medication is taken throughout the day without a "nitrate-free period" (a 10-to-12-hour break from the medication). If you find that your symptoms of angina are getting worse or lasting longer, call your doctor.

Withdrawal: Stopping this medication suddenly may occasionally aggravate chest pain or other symptoms of angina. To avoid possible withdrawal effects, isosorbide dinitrate should be gradually reduced and not stopped suddenly. Talk to your doctor about how to stop the medication safely.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if isosorbide dinitrate passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors may be more likely to experience dizziness or lightheadedness taking isosorbide dinitrate.

What other drugs could interact with ISDN?

There may be an interaction between isosorbide dinitrate and any of the following:

  • alcohol
  • ergot alkaloids
  • medications that reduce blood pressure
  • medications for erectile dysfunction called PDE-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • rosiglitazone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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