October 25, 2014
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Drug Factsheets

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MacroBid

(nitrofurantoin monohydrate - nitrofurantoin macrocrystals)

DIN (Drug Identification Number)

02063662 MACROBID 100MG CAPSULE

What side effects are possible with MacroBid?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • gas
  • headache
  • nausea

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • confusion
  • hair loss
  • joint or muscle pain
  • mood swings, unusual thoughts, or unusual behavior
  • symptoms of liver problems (such as yellow eyes or skin, abdominal pain, pale stools, dark urine, itching, nausea, or fatigue)
  • symptoms of low white blood cells (such as fever and chills or frequent infections)
  • symptoms of low red blood cells (such as fatigue, weakness, decreased energy, or pale skin)
  • symptoms of nerve damage (such as tingling, burning, pain, or numbness in the arms and legs; or difficulty controlling the muscles in the arms or legs)
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a lung reaction to the medication (such as fever, chills, cough, chest pain, or difficulty breathing)
  • symptoms of a serious skin reaction (such as a severe blistering skin rash that causes the skin to peel or fall off; fever; or bloodshot eyes)
  • symptoms of a severe allergic reaction (such as hives, difficulty breathing, and swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for MacroBid?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Discoloration of urine: This medication may turn your urine a rust yellow or brown colour. This is a normal effect of the medication and is not a cause for concern.

Overgrowth of organisms: The use of this medication may cause an overgrowth of microorganisms not killed by the medication, with results such as yeast infections and resistant bacteria.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Do not use this medication if you are in labour or expect to go into labour soon (i.e., you are close to your due date). If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking nitrofurantoin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children under one month of age.

What other drugs could interact with MacroBid?

There may be an interaction between nitrofurantoin and any of the following:

  • antacids containing magnesium
  • bacillus Calmette-Guerin (BCG)
  • probenecid
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin)
  • sulfinpyrazone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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