September 1, 2014

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Apo-Diltiaz CD


DIN (Drug Identification Number)


What side effects are possible with Apo-Diltiaz CD?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • diarrhea
  • dizziness or lightheadedness
  • flushing
  • headache
  • heartburn
  • nausea
  • nervousness
  • tiredness or weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • breathing difficulty, coughing, or wheezing
  • fainting
  • irregular or fast, pounding heartbeat
  • skin rash
  • slow heartbeat (less than 50 beats per minute)
  • swelling of ankles, feet, or lower legs
  • vomiting

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for Apo-Diltiaz CD?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood pressure: Diltiazem may lower blood pressure too much in certain cases. If you experience lightheadedness, weakness, or dizziness, talk to your doctor.

Congestive heart failure: If you have congestive heart failure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Heart rhythm problems: In people with certain types of heart rhythm problems (sick sinus syndrome, second- and third-degree atrio-ventricular block) who do not have pacemakers, diltiazem may cause abnormally slow heart rates. People with certain types of heart rhythm problems should not take diltiazem. If you have a heart rhythm problem, your doctor should monitor your condition while you are taking diltiazem. Talk to your doctor if you have any concerns.

Kidney or liver problems: Diltiazem is broken down in the body by the kidneys and liver. The dosage may have to be lowered for people with reduced kidney or liver function. Your doctor will perform tests regularly to monitor your liver and kidney function.

Pregnancy: Women who are or may become pregnant should not take diltiazem.

Breast-feeding: Diltiazem passes into breast milk. If you are a breast-feeding mother and are taking diltiazem, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of diltiazem for children has not been established.

What other drugs could interact with Apo-Diltiaz CD?

There may be an interaction between diltiazem and any of the following:

  • amiodarone
  • anaesthetics
  • azole antifungals (e.g., fluconazole, ketoconazole, itraconazole)
  • benzodiazepines (e.g., triazolam, midazolam)
  • corticosteroids
  • beta-adrenergic blocking agents (e.g., atenolol, labetalol, metoprolol)
  • carbamazepine
  • cimetidine
  • cyclosporine
  • digoxin
  • disopyramide
  • erythromycin
  • flecainide
  • imipramine
  • phenobarbital
  • phenytoin
  • procainamide
  • propafenone
  • quinidine
  • rifampin
  • theophylline
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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