April 24, 2014
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Drug Factsheets

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Premarin

(conjugated estrogens)

DIN (Drug Identification Number)

02043394 PREMARIN 0.3MG TABLET
02043408 PREMARIN 0.625MG TABLET
02043424 PREMARIN 1.25MG TABLET

How does Premarin work? What will it do for me?

Conjugated estrogens belong to the class of medications known as estrogen replacement therapy. Estrogen is a female hormone that is produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and symptoms of menopause can occur. Conjugated estrogen is an estrogen replacement hormone used to manage menopausal symptoms such as abnormal uterine bleeding (spotting), hot flashes, sweating, and chills. This medication may also help treat and prevent osteoporosis caused by estrogen deficiency when combined with diet, calcium, and exercise.

For women who are not having menopause symptoms, this medication should only be used if the woman is at serious risk of osteoporosis and cannot take other medications normally given to prevent osteoporosis. It may also be used to treat a condition where the tissues of the vagina become weak (vaginal atrophy or atrophic vaginitis), but if a woman is not having any other symptoms of menopause, an estrogen product applied to the skin (such as a cream) may be an more appropriate choice. It is also used to replace estrogen hormones in situations where the body can no longer produce estrogen, and to treat men with inoperable progressing prostate cancer when other treatments have not worked.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Premarin?

The recommended adult dose of conjugated estrogens ranges from 0.3 mg to 1.25 mg daily, depending on the condition being treated. It is recommended that this medication be taken at the lowest dose possible and for the shortest duration required to treat the condition. It is important to have regular checkups with your doctor to decide if this medication is still necessary. Tablets can either be taken every day or in a cycle, such as 25 days on the medication each month and 5 days off.

Women who have not had their uterus removed should also take a progestogen (a different type of female hormone that protects the uterus from potential harmful effects caused by estrogen) for 10 to 14 days each month, or every day depending on the hormone strength and whether a menstrual period is desired or not. Talk with your doctor or pharmacist about the advantages and disadvantages of the different dosing schedules of estrogen and progestogen.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does Premarin come in?

0.3 mg
Each green, oval, sugar-coated tablet, imprinted with "Premarin", contains 0.3 mg of conjugated estrogens. Nonmedicinal ingredients: calcium phosphate tribasic, calcium sulfate anhydrous, carnauba wax, D&C Yellow No. 10, edible ink, FD&C Blue No. 1, FD&C Yellow No. 6, glyceryl monooleate, lactose, magnesium stearate, methylcellulose, methylparaben, microcrystalline cellulose, polyethylene glycol, polysorbate 60, polyvinylpyrrolidone, propylparaben, shellac, sodium benzoate, sucrose, sucrose syrup, and titanium dioxide. This medication does not contain alcohol, gluten, sulfites, or tartrazine.

0.625 mg
Each maroon, oval, sugar-coated tablet, imprinted with "Premarin", contains 0.625 mg of conjugated estrogens. Nonmedicinal ingredients: calcium phosphate tribasic, calcium sulfate anhydrous, carnauba wax, edible ink, FD&C Blue No. 2, FD&C Red No. 3, FD&C Yellow No. 6, glyceryl monooleate, gum acacia, lactose, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, polysorbate 60, propylparaben, shellac, sodium benzoate, sucrose, sucrose syrup, and titanium dioxide. This medication does not contain alcohol, gluten, sulfites, or tartrazine.

1.25 mg
Each yellow, oval, sugar-coated tablet, imprinted with "Premarin", contains 1.25 mg of conjugated estrogens. Nonmedicinal ingredients: calcium phosphate tribasic, calcium sulfate anhydrous, carnauba wax, D&C Yellow No. 10, edible ink, FD&C Yellow No. 6, glyceryl monooleate, lactose, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, polysorbate 60, propylparaben, shellac, sucrose, and titanium dioxide. This medication does not contain alcohol, gluten, sulfites, or tartrazine.

Who should NOT take Premarin?

Conjugated estrogens should not be taken by anyone who:

  • is allergic to conjugated estrogens or to any of the ingredients of the medication
  • is or may be pregnant
  • has a history of known or suspected estrogen-dependent tumours such as breast or uterine cancer
  • has active liver disease or dysfunction
  • has active thrombophlebitis, thrombosis, or thromboembolic disorders (blood clotting problems)
  • has endometrial hyperplasia (increase in the thickness of the lining of the uterus)
  • has had partial or complete loss of vision due to blood vessel-related eye disease
  • has undiagnosed abnormal vaginal bleeding

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