December 18, 2014
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C.E.S.

(conjugated estrogens)

DIN (Drug Identification Number)

00265470 C.E.S. 0.625MG TABLET

How does C.E.S. work? What will it do for me?

Conjugated estrogens belong to the class of medications known as estrogen replacement therapy. Estrogen is a female hormone that is produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and symptoms of menopause can occur. Conjugated estrogen is an estrogen replacement hormone used to manage menopausal symptoms such as abnormal uterine bleeding (spotting), hot flashes, sweating, and chills. This medication may also help treat and prevent osteoporosis caused by estrogen deficiency when combined with diet, calcium, and exercise.

For women who are not having menopause symptoms, this medication should only be used if the woman is at serious risk of osteoporosis and cannot take other medications normally given to prevent osteoporosis. It may also be used to treat a condition where the tissues of the vagina become weak (vaginal atrophy or atrophic vaginitis), but if a woman is not having any other symptoms of menopause, an estrogen product applied to the skin (such as a cream) may be an more appropriate choice. It is also used to replace estrogen hormones in situations where the body can no longer produce estrogen, and to treat men with inoperable progressing prostate cancer when other treatments have not worked.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use C.E.S.?

The recommended adult dose of conjugated estrogens ranges from 0.3 mg to 1.25 mg daily, depending on the condition being treated. The usual adult starting dose is 0.3 mg daily, which may be increased gradually until you get relief from your symptoms. It is recommended that this medication be taken at the lowest dose possible and for the shortest duration required to treat the condition. It is important to have regular checkups with your doctor to decide if this medication is still necessary. Tablets can either be taken every day or in a cycle, such as 25 days on the medication each month and 5 days off.

Women who have not had their uterus removed should also take a progestogen (a different type of female hormone that protects the uterus from potential harmful effects caused by estrogen) for 10 to 14 days each month, or every day depending on the hormone strength and whether a menstrual period is desired or not. Talk with your doctor or pharmacist about the advantages and disadvantages of the different dosing schedules of estrogen and progestogen.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does C.E.S. come in?

0.625 mg
Each oval, maroon, sugar-coated tablet contains 0.625 mg of conjugated estrogens CSD. Nonmedicinal ingredients: CSD, calcium carbonate, calcium phosphate, calcium sulphate, carnauba wax, colloidal silicon dioxide, lactose, magnesium carbonate, FD&C Blue No. 2, FD&C Red No. 40, methylparaben, microcrystalline cellulose, povidone, sodium benzoate, starch, sucrose, talc, titanium dioxide, stearic acid, and white wax.

Who should NOT take C.E.S.?

Do not take conjugated estrogens if you:

  • are allergic to conjugated estrogens or any ingredients of the medication
  • are or may be pregnant
  • have a history of known or suspected estrogen-dependent tumours such as breast or uterine cancer
  • have active liver disease or dysfunction
  • have active thrombophlebitis, thrombosis, or thromboembolic disorders (blood clotting problems)
  • have or have had stroke, heart attack or coronary heart disease
  • have endometrial hyperplasia (increase in the thickness of the lining of the uterus)
  • have had partial or complete loss of vision due to blood vessel-related eye disease
  • have undiagnosed abnormal vaginal bleeding
  • have migraine with or without aura

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