September 15, 2014
ABCDEFGHIJKLMNOPQRSTUVWXYZ

Drug Factsheets

 Health Home >> Medications 

Prometrium

(progesterone (for hormone replacement therapy))

DIN (Drug Identification Number)

02166704 PROMETRIUM 100MG CAPSULE

What side effects are possible with Prometrium?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain or cramping
  • acne
  • breast pain or tenderness
  • brown spots on exposed skin, possibly long-lasting
  • dizziness
  • drowsiness
  • lightheadedness
  • change of sexual desire
  • loss or gain of body, facial, or scalp hair
  • mood changes
  • nervousness
  • swelling of face, ankles, or feet
  • tiredness
  • trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • allergic reaction (e.g., hives, skin rash, itchiness)
  • changes in vaginal bleeding, such as:
    • heavier vaginal bleeding between regular monthly periods
    • increased amounts of menstrual bleeding occurring at regular monthly periods
    • lighter vaginal bleeding between menstrual periods
    • stopping of menstrual periods
  • painful urination
  • pain during sexual intercourse
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • worsening headaches or migraines

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a blood clot in blood vessels, such as sudden vision change or dizziness, chest pain, pain and swelling in one leg muscle
  • signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Prometrium?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Important information about estrogen:

  • Estrogen should be used at the lowest dose that relieves your menopausal symptoms for the shortest time period possible.
  • You should not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.

Breast cancer: Several studies have shown an association between a modest increase in the risk of developing breast cancer and the use of hormone replacement therapy during menopause when taken over the long term. Ask your doctor which breast cancer screening tests you may need and how to perform breast self-examination.

Depression: Hormones, such as progesterone, have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication contact your doctor as soon as possible.

Diabetes: As with other hormone replacement medications, progesterone may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Occupational hazards: Temporary and occasional drowsiness or dizziness may occur for some people one to four hours after taking progesterone, particularly if it is taken with food. If this occurs, avoid activities requiring concentration, good coordination, or reflex action such as driving or operating machinery. In most cases, these problems can be prevented by taking the capsules at the recommended times. The 200 mg dosage should be taken at bedtime. The 300 mg dosage should be divided into two doses: 100 mg 2 hours after breakfast and 200 mg at bedtime.

Vaginal bleeding: Progesterone can cause changes to your normal pattern of vaginal bleeding. If you experience menstrual bleeding that lasts longer or heavier than usual, contact your doctor.

Pregnancy: Do not take progesterone during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking progesterone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with Prometrium?

There may be an interaction between progesterone and any of the following:

  • aliskiren
  • amiodarone
  • apixaban
  • argatroban
  • barbiturates (e.g., pentobarbital, phenobarbital)
  • bosentan
  • bosutinib
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • carbamazepine
  • carvedilol
  • cetirizine
  • ciprofloxacin
  • colchicine
  • cyclosporine
  • dabigatran
  • dabrafenib
  • daunorubicin
  • deferasirox
  • dexamethasone
  • digoxin
  • dofetilide
  • doxorubicin
  • etoposide
  • everolimus
  • estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
  • fluconazole
  • fluvoxamine
  • gemfibrozil
  • "gliptin" diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
  • heparin
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
  • hydrocortisone
  • idarubicin
  • imatinib
  • indinavir
  • irinotecan
  • isoniazid
  • ivermectin
  • ketoconazole
  • loperamide
  • lopinavir
  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • methotrexate
  • mitotane
  • nadolol
  • nelfinavir
  • ondansetron
  • oxcarbazepine
  • paclitaxel
  • paliperidone
  • pazopanib
  • phenytoin
  • pimozide
  • primidone
  • prucalopride
  • quinidine
  • quinine
  • ranitidine
  • rifabutin
  • rifampin
  • risperidone
  • ritonavir
  • rivaroxaban
  • romidepsin
  • St. John's wort
  • saquinavir
  • silodosin
  • sirolimus
  • "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • tacrolimus
  • telaprevir
  • temsirolimus
  • ticlopidine
  • tocilizumab
  • tolvaptan
  • topotecan
  • trabectedin
  • ulipristal
  • vinblastine
  • vincristine
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Previous | 1 | 2 | 


Did you find what you were looking for on our website? Please let us know.

Ad

The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical condition(s) and treatment(s). This site is not a substitute for medical advice.

© 1996 - 2014 MediResource Inc. - MediResource reaches millions of Canadians each year.