April 23, 2014
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Drug Factsheets

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Apo-Methoprazine

(methotrimeprazine)

DIN (Drug Identification Number)

02238405 APO-METHOPRAZINE 25MG TABLET
02238403 APO-METHOPRAZINE 2MG TABLET
02238406 APO-METHOPRAZINE 50MG TABLET
02238404 APO-METHOPRAZINE 5MG TABLET

What side effects are possible with Apo-Methoprazine?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Drowsiness may appear early in treatment but will gradually disappear during the first weeks or with an adjustment in the dosage.
  • Dryness of the mouth and, in older patients, occasional urinary retention, constipation, and fast heart rate may occur.

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • high blood sugar (symptoms include increased thirst, decreased appetite, nausea and vomiting)
  • low blood pressure (symptoms include dizziness, especially when moving to a standing position)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • allergic reactions, such as skin rash, redness, or itching
  • fast or irregular heartbeat, high or low blood pressure
  • increased sweating, confusion, or reduced consciousness
  • muscle twitching or uncontrolled movements of the mouth, tongue, face, or jaw
  • pain, swelling , redness, or warmth in arms or legs, chest pain, anxiety, or coughing up blood
  • painful erection lasting more than 4 hours
  • respiratory infection, fever, flu-like symptoms, coughing, difficult or fast breathing
  • shaking, muscle stiffness, body spasm, impairment of voluntary movement, upward eye rolling, exaggeration of reflexes or drooling
  • sore mouth, gums, or throat; abdominal pain; or jaundice (yellow eyes or skin)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Apo-Methoprazine?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

June 15, 2011

Health Canada has issued information concerning the use of methotrimeprazine. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Diabetes: If you have diabetes, your doctor should closely monitor your condition while you are taking methotrimeprazine, as it may affect blood sugar control.

Dizziness/lightheadedness: In high doses, dizziness or lightheadedness when getting up from a sitting or lying position may be experienced at the start of treatment.

Drowsiness/reduced alertness: Methotrimeprazine can cause drowsiness and reduce alertness, especially during the first few days of treatment. Do not drive or participate in activities requiring mental alertness if the medication affects you in this way.

Medical conditions: If you have arteriosclerosis, heart problems, glaucoma, or prostate problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if methotrimeprazine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with Apo-Methoprazine?

There may be an interaction between methotrimeprazine and any of the following:

  • antihistamines (e.g., diphenhydramine)
  • barbiturates (e.g., phenobarbital)
  • dronedarone
  • metoclopramide
  • narcotics (e.g., codeine, morphine)
  • nilotinib
  • other phenothiazines (e.g., chlorpromazine)
  • pimozide
  • quinine
  • tamoxifen
  • tetrabenazine
  • ziprasidone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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