August 28, 2014
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Drug Factsheets

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Dexilant

(dexlansoprazole)

DIN (Drug Identification Number)

02354950 DEXILANT 30MG CAPSULE (DELAYED RELEASE)
02354969 DEXILANT 60MG CAPSULE (DELAYED RELEASE)

What side effects are possible with Dexilant?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • constipation
  • diarrhea
  • gas
  • headache
  • nausea

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • symptoms of liver damage (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • convulsion or seizure
  • signs of a severe skin reaction (e.g., high fever; rash; skin peeling off; or painful blisters on the skin, mouth, or eyes)
  • symptoms of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing, wheezing, or itchy skin rash)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.





Are there any other precautions or warnings for Dexilant?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

April 4, 2013

Health Canada has issued new information concerning the use of Dexilant® (dexlansoprazole). To read the full report, visit Health Canada's website at www.hc-sc.gc.ca.

Previous advisories on Dexilant® were issued on February 16, 2012 and on October 19, 2012.

To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Fractures: Long-term use of proton-pump inhibitors has been associated with an increased risk for osteoporosis-related fracture of the hip, wrist, or spine. Talk to your doctor if you have any concerns.

Liver problems: People with liver problems should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Other stomach problems: Even if you experience improvement in acid-related symptoms, it is still possible to have serious underlying stomach problems such as stomach cancer. Talk to your doctor if you have other symptoms of stomach problems such as loss of appetite, nausea, vomiting, a bloated feeling after eating, changes in bowel habits, or unexplained weight loss or fatigue.

Pregnancy: This medication should not be taken during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if dexlansoprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with Dexilant?

There may be an interaction between dexlansoprazole and any of the following:

  • ampicillin
  • atazanavir
  • clopidogrel
  • dasatinib
  • digoxin
  • erlotinib
  • iron supplements
  • itraconazole
  • ketoconazole
  • mesalamine
  • methotrexate
  • nelfinavir
  • posaconazole
  • tacrolimus
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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